ArticleMolecular and cellular biology1994
The GATA-4 transcription factor transactivates the cardiac muscle-specific troponin C promoter-enhancer in nonmuscle cells.
Article in Molecular and cellular biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 187 citations in OpenAlex.
- Uncovering the Genetic Basis of Congenital Heart Disease: Recent Advancements and Implications for Clinical Management.CJC pediatric and congenital heart disease · 2023Review
- The transcriptional factor GATA-4 negatively regulates Hsp70 transcription in Crassostrea hongkongensis.Molecular biology reports · 2020Article
- Targeting GATA4 for cardiac repair.IUBMB life · 2020Review
- Article
- Gata4 regulates hedgehog signaling and Gata6 expression for outflow tract development.PLoS genetics · 2019Article
- Reduced dosage of β-catenin provides significant rescue of cardiac outflow tract anomalies in a Tbx1 conditional null mouse model of 22q11.2 deletion syndrome.PLoS genetics · 2017Article
- Gata4 potentiates second heart field proliferation and Hedgehog signaling for cardiac septation.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Pias1 is essential for erythroid and vascular development in the mouse embryo.Developmental biology · 2016Article
- Multipotency and cardiomyogenic potential of human adipose-derived stem cells from epicardium, pericardium, and omentum.Stem cell research & therapy · 2016Article
- Arsenic trioxide alters the differentiation of mouse embryonic stem cell into cardiomyocytes.Scientific reports · 2015Article
- GATA4 transgenic mice as an in vivo model of congenital heart disease.International journal of molecular medicine · 2015Article
- Mouse models for the study of postnatal cardiac hypertrophy.International journal of cardiology. Heart & vasculature · 2015Article
- Article
- Lrrc10 is a novel cardiac-specific target gene of Nkx2-5 and GATA4.Journal of molecular and cellular cardiology · 2013Article
- Myocardin regulates BMP10 expression and is required for heart development.The Journal of clinical investigation · 2012Article
- Cell signaling pathways for the regulation of GATA4 transcription factor: Implications for cell growth and apoptosis.Cellular signalling · 2011Article
- Mesenchymal stem cells or cardiac progenitors for cardiac repair? A comparative study.Cellular and molecular life sciences : CMLS · 2011Article
- Myocardin marks the earliest cardiac gene expression and plays an important role in heart development.Anatomical record (Hoboken, N.J. : 2007) · 2008Article
- Tissue specific promoters improve specificity of AAV9 mediated transgene expression following intra-vascular gene delivery in neonatal mice.Genetic vaccines and therapy · 2008Article
- Identification of downstream genetic pathways of Tbx1 in the second heart field.Developmental biology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The unique contractile phenotype of cardiac myocytes is determined by the expression of a set of cardiac muscle-specific genes. By analogy to other mammalian developmental systems, it is likely that the coordinate expression of cardiac genes is controlled by lineage-specific transcription factors that interact with promoter and enhancer elements in the transcriptional regulatory regions of these genes. Although previous reports have identified several cardiac muscle-specific transcriptional elements, relatively little is known about the lineage-specific transcription factors that regulate these elements. In this report, we demonstrate that the slow/cardiac muscle-specific troponin C (cTnC) enhancer contains a specific binding site for the lineage-restricted zinc finger transcription factor GATA-4. This GATA-4-binding site is required for enhancer activity in primary cardiac myocytes. Moreover, the cTnC enhancer can be transactivated by overexpression of GATA-4 in non-cardiac muscle cells such as NIH 3T3 cells. In situ hybridization studies demonstrate that GATA-4 and cTnC have overlapping patterns of expression in the hearts of postimplantation mouse embryos and that GATA-4 gene expression precedes cTnC expression. Indirect immunofluorescence reveals GATA-4 expression in cultured cardiac myocytes from neonatal rats. Taken together, these results are consistent with a model in which GATA-4 functions to direct tissue-specific gene expression during mammalian cardiac development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.