ArticleMolecular and cellular biology1994
Differential effects of Cdc68 on cell cycle-regulated promoters in Saccharomyces cerevisiae.
Article in Molecular and cellular biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- Essential histone chaperones collaborate to regulate transcription and chromatin integrity.Genes & development · 2021Article
- Chromatin and transcription in yeast.Genetics · 2012Review
- Insight into the mechanism of nucleosome reorganization from histone mutants that suppress defects in the FACT histone chaperone.Genetics · 2011Article
- Histone Chaperones Spt6 and FACT: Similarities and Differences in Modes of Action at Transcribed Genes.Genetics research international · 2011Article
- FACT prevents the accumulation of free histones evicted from transcribed chromatin and a subsequent cell cycle delay in G1.PLoS genetics · 2010Article
- The E2F functional analogue SBF recruits the Rpd3(L) HDAC, via Whi5 and Stb1, and the FACT chromatin reorganizer, to yeast G1 cyclin promoters.The EMBO journal · 2009Article
- New mutant versions of yeast FACT subunit Spt16 affect cell integrity.Molecular genetics and genomics : MGG · 2009Article
- FACT and Asf1 regulate nucleosome dynamics and coactivator binding at the HO promoter.Molecular cell · 2009Article
- Article
- Modulation of nucleosome-binding activity of FACT by poly(ADP-ribosyl)ation.Nucleic acids research · 2006Article
- Genetic interactions between mediator and the late G1-specific transcription factor Swi6 in Saccharomyces cerevisiae.Genetics · 2005Article
- A coordinated temporal interplay of nucleosome reorganization factor, sister chromatin cohesion factor, and DNA polymerase alpha facilitates DNA replication.Molecular and cellular biology · 2004Article
- Domain organization of the yeast histone chaperone FACT: the conserved N-terminal domain of FACT subunit Spt16 mediates recovery from replication stress.Nucleic acids research · 2004Article
- The FACT complex travels with elongating RNA polymerase II and is important for the fidelity of transcriptional initiation in vivo.Molecular and cellular biology · 2003Article
- The high-mobility-group box protein SSRP1/T160 is essential for cell viability in day 3.5 mouse embryos.Molecular and cellular biology · 2003Article
- Spt16-Pob3 and the HMG protein Nhp6 combine to form the nucleosome-binding factor SPN.The EMBO journal · 2001Article
- A bipartite yeast SSRP1 analog comprised of Pob3 and Nhp6 proteins modulates transcription.Molecular and cellular biology · 2001Article
- POB3 is required for both transcription and replication in the yeast Saccharomyces cerevisiae.Genetics · 2000Article
- The yeast protein complex containing cdc68 and pob3 mediates core-promoter repression through the cdc68 N-terminal domain.Genetics · 1998Article
- Nuclear proteins Nut1p and Nut2p cooperate to negatively regulate a Swi4p-dependent lacZ reporter gene in Saccharomyces cerevisiae.Molecular and cellular biology · 1998Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Swi4 and Swi6 form a complex which is required for Start-dependent activation of HO and for high-level expression of G1 cyclin genes CLN1 and CLN2. To identify other regulators of this pathway, we screened for dominant, recessive, conditional, and allele-specific suppressors of swi4 mutants. We isolated 16 recessive suppressors that define three genes, SSF1, SSF5, and SSF9 (suppressor of swi four). Mutations in all three genes bypass the requirement for both Swi4 and Swi6 for HO transcription and activate transcription from reporter genes lacking upstream activating sequences (UASs). SSF5 is allelic with SIN4 (TSF3), a gene implicated in global repression of transcription and chromatin structure, and SSF9 is likely to be a new global repressor of transcription. SSF1 is allelic with CDC68 (SPT16). cdc68 mutations have been shown to increase expression from defective promoters, while preventing transcription from other intact promoters, including CLN1 and CLN2. We find that CDC68 is a required activator of both SWI4 and SWI6, suggesting that CDC68's role at the CLN promoters may be indirect. The target of CDC68 within the SWI4 promoter is complex in that known activating elements (MluI cell cycle boxes) in the SWI4 promoter are required for CDC68 dependence but only within the context of the full-length promoter. This result suggests that there may be both a chromatin structure and a UAS-specific component to Cdc68 function at SWI4. We suggest that Cdc68 functions both in the assembly of repressive complexes that form on many intact promoters in vivo and in the relief of this repression during gene activation.
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