ArticleMolecular and cellular biology1994
The human immunodeficiency virus type 1 Rev protein shuttles between the cytoplasm and nuclear compartments.
Article in Molecular and cellular biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed.
- Human Retrovirus Genomic RNA Packaging.Viruses · 2022Review
- Differential fates of introns in gene expression due to global alternative splicing.Human genetics · 2022Review
- Dual Pro- and Anti-Inflammatory Features of Monocyte-Derived Dendritic Cells.Frontiers in immunology · 2020Article
- Intron retention in viruses and cellular genes: Detention, border controls and passports.Wiley interdisciplinary reviews. RNA · 2018Review
- Proteolytic activity assayed by subcellular localization switching of a substrate.Biochemistry and biophysics reports · 2016Article
- Comparative Analysis of Tat-Dependent and Tat-Deficient Natural Lentiviruses.Veterinary sciences · 2015Review
- HIV-1 Rev downregulates Tat expression and viral replication via modulation of NAD(P)H:quinine oxidoreductase 1 (NQO1).Nature communications · 2015Article
- RNA Export through the NPC in Eukaryotes.Genes · 2015Review
- Mapping the binding interface between an HIV-1 inhibiting intrabody and the viral protein Rev.PloS one · 2013Article
- Formation of trans-activation competent HIV-1 Rev:RRE complexes requires the recruitment of multiple protein activation domains.PloS one · 2012Article
- Molecular determinants responsible for the subcellular localization of HSV-1 UL4 protein.Virologica Sinica · 2011Article
- Translational regulation of HIV-1 replication by HIV-1 Rev cellular cofactors Sam68, eIF5A, hRIP, and DDX3.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2011Article
- An intrabody based on a llama single-domain antibody targeting the N-terminal alpha-helical multimerization domain of HIV-1 rev prevents viral production.The Journal of biological chemistry · 2010Article
- The alcelaphine herpesvirus-1 ORF 57 encodes a nuclear shuttling protein.Veterinary research communications · 2009Article
- Nucleolus: the fascinating nuclear body.Histochemistry and cell biology · 2008Review
- Apoptin nucleocytoplasmic shuttling is required for cell type-specific localization, apoptosis, and recruitment of the anaphase-promoting complex/cyclosome to PML bodies.Journal of virology · 2006Article
- HIV-1 Rev oligomerization is not obligatory in the presence of an extra basic domain.Retrovirology · 2005Article
- SLBP is associated with histone mRNA on polyribosomes as a component of the histone mRNP.Nucleic acids research · 2004Article
- hRIP, a cellular cofactor for Rev function, promotes release of HIV RNAs from the perinuclear region.Genes & development · 2004Article
- A synthetic HIV-1 Rev inhibitor interfering with the CRM1-mediated nuclear export.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A retroviral regulatory protein, Rev (regulator of virion protein expression), is made in cells infected by human immunodeficiency virus (HIV). Rev is essential for the completion of the retroviral life cycle and interacts with the host cell at some posttranscriptional step in order to express the incompletely spliced HIV mRNAs from which HIV structural proteins are translated. Neither the host cell components nor the mechanisms responsible for this important regulation have been defined. We now report that Rev is a nucleocytoplasmic shuttle protein which is continuously transported between the cytoplasm, the nucleoli, and nucleoplasmic speckles enriched in RNA splicing and processing factors. The results show that Rev has the potential to interfere specifically with the splicing of the HIV pre-mRNA in the nucleoplasm and, next, guide such mRNAs to the cytoplasm for translation.
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