ArticleMolecular and cellular biology1994
The opposite and antagonistic effects of the closely related POU family transcription factors Brn-3a and Brn-3b on the activity of a target promoter are dependent on differences in the POU domain.
Article in Molecular and cellular biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 68 citations in OpenAlex.
- Essential but partially redundant roles for POU4F1/Brn-3a and POU4F2/Brn-3b transcription factors in the developing heart.Cell death & disease · 2017Article
- Article
- Towards an understanding of the herpes simplex virus type 1 latency-reactivation cycle.Interdisciplinary perspectives on infectious diseases · 2010Article
- The HPV Cellular Transactivator Brn-3a Can Be Used to Predict Cervical Adenocarcinoma and Squamous Carcinoma Precancer Lesions in the Developed and Developing Worlds.Obstetrics and gynecology international · 2009Article
- Differential regulation of different human papilloma virus variants by the POU family transcription factor Brn-3a.Oncogene · 2006Article
- Article
- Herpes simplex virus type 1 and bovine herpesvirus 1 latency.Clinical microbiology reviews · 2003Review
- Abnormal chemosensory jump 6 is a positive transcriptional regulator of the cholinergic gene locus in Drosophila olfactory neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- A minimal Bcl-x promoter is activated by Brn-3a and repressed by p53.Nucleic acids research · 2001Article
- Article
- The Brn-3a transcription factor plays a key role in regulating the growth of cervical cancer cells in vivo.Oncogene · 2001Article
- The Brn-3b POU family transcription factor represses expression of the BRCA-1 anti-oncogene in breast cancer cells.Oncogene · 1999Article
- Autoregulatory sequences are revealed by complex stability screening of the mouse brn-3.0 locus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Dominant negative murine serum response factor: alternative splicing within the activation domain inhibits transactivation of serum response factor binding targets.Molecular and cellular biology · 1999Article
- The N-terminal domain unique to the long form of the Brn-3a transcription factor is essential to protect neuronal cells from apoptosis and for the activation of Bbcl-2 gene expression.Nucleic acids research · 1998Article
- The HPV-activating cellular transcription factor Brn-3a is overexpressed in CIN3 cervical lesions.The Journal of clinical investigation · 1998Article
- POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element.Molecular and cellular biology · 1998Article
- Concerted activity of host cell factor subregions in promoting stable VP16 complex assembly and preventing interference by the acidic activation domain.Molecular and cellular biology · 1997Article
- Identification of a novel repressive element that contributes to neuron-specific gene expression.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- POU domain factors of the Brn-3 class recognize functional DNA elements which are distinctive, symmetrical, and highly conserved in evolution.Molecular and cellular biology · 1997Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Brn-3a, Brn-3b, and Brn-3c POU family transcription factors are closely related to one another and are members of the group IV subfamily of POU factors. Here we show that despite this close relationship, the factors have different effects on the activity of a target promoter: Brn-3a and Brn-3c stimulate the promoter whereas Brn-3b represses it. Moreover, Brn-3b can antagonize the stimulatory effect of Brn-3a on promoter activity and can also inhibit promoter activation by the Oct-2.1 POU factor. The difference in the transactivation activities of Brn-3a and Brn-3b is dependent upon the C-terminal region containing the POU domain of the two proteins, since exchange of this domain between the two factors converts Brn-3a into a repressor and Brn-3b into an activator.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.