ArticleMolecular and cellular biology1994
Identification of a C/EBP-Rel complex in avian lymphoid cells.
Article in Molecular and cellular biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 42 citations in OpenAlex.
- Inflammation and hypoxia linked to renal injury by CCAAT/enhancer-binding protein δ.Kidney international · 2015Article
- Mechanism of differentiation-enhanced photodynamic therapy for cancer: upregulation of coproporphyrinogen oxidase by C/EBP transcription factors.Molecular cancer therapeutics · 2013Article
- Article
- C/EBPbeta regulation in lipopolysaccharide-stimulated macrophages.Molecular and cellular biology · 2003Article
- NF-kappa B-dependent assembly of an enhanceosome-like complex on the promoter region of apoptosis inhibitor Bfl-1/A1.Molecular and cellular biology · 2003Article
- Transcriptional repression of human hepatitis B virus genes by a bZIP family member, E4BP4.Journal of virology · 1999Article
- Overexpression of C/EBPbeta represses human papillomavirus type 18 upstream regulatory region activity in HeLa cells by interfering with the binding of TATA-binding protein.Journal of virology · 1998Article
- VBP and RelA regulate avian leukosis virus long terminal repeat-enhanced transcription in B cells.Journal of virology · 1997Article
- Adenovirus E3-10.4K/14.5K protein complex inhibits tumor necrosis factor-induced translocation of cytosolic phospholipase A2 to membranes.Journal of virology · 1997Article
- Regulation of the cfos serum response element by C/EBPbeta.Molecular and cellular biology · 1997Article
- Involvement of Egr-1/RelA synergy in distinguishing T cell activation from tumor necrosis factor-alpha-induced NF-kappa B1 transcription.The Journal of experimental medicine · 1997Article
- A novel C/EBP beta-YY1 complex controls the cell-type-specific activity of the human papillomavirus type 18 upstream regulatory region.Journal of virology · 1996Article
- Multiple steps in the regulation of transcription-factor level and activity.The Biochemical journal · 1996Review
- Regulation of avian leukosis virus long terminal repeat-enhanced transcription by C/EBP-Rel interactions.Journal of virology · 1996Article
- Avian I kappa B alpha is transcriptionally induced by c-Rel and v-Rel with different kinetics.Journal of virology · 1995Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein-protein interactions between the CCAAT box enhancer-binding proteins (C/EBP) and the Rel family of transcription factors have been implicated in the regulation of cytokine gene expression. We have used sequence-specific DNA affinity chromatography to purify a complex from avian T cells that binds to a consensus C/EBP motif. Our results provide evidence that Rel-related proteins are components of the C/EBP-DNA complex as a result of protein-protein interactions with the C/EBP proteins. A polyclonal antiserum raised against the Rel homology domain of v-Rel and antisera raised against two human RelA-derived peptides specifically induced a supershift of the C/EBP-DNA complex in mobility shift assays using the affinity-purified C/EBP. In addition, several kappa B-binding proteins copurified with the avian C/EBP complex through two rounds of sequence-specific DNA affinity chromatography. The kappa B-binding proteins are distinct from the C/EBP proteins that directly contact DNA containing the C/EBP binding site. The identification of a protein complex that binds specifically to a consensus C/EBP site and contains both C/EBP and Rel family members suggests a novel mechanism for regulation of gene expression by Rel family proteins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.