ArticleJournal of molecular evolution1994
Convergent evolution of crystallin gene regulation in squid and chicken: the AP-1/ARE connection.
Article in Journal of molecular evolution, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 42 citations in OpenAlex.
- Evolutionary Origins of Pax6 Control of Crystallin Genes.Genome biology and evolution · 2017Article
- Molecular Evidence for Convergence and Parallelism in Evolution of Complex Brains of Cephalopod Molluscs: Insights from Visual Systems.Integrative and comparative biology · 2015Article
- Large Maf Transcription Factors: Cousins of AP-1 Proteins and Important Regulators of Cellular Differentiation.The Einstein journal of biology and medicine : EJBM · 2007Article
- Vertebrate-like betagamma-crystallins in the ocular lenses of a copepod.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2005Article
- JNK initiates a cytokine cascade that causes Pax2 expression and closure of the optic fissure.Genes & development · 2003Article
- Crystallin genes: specialization by changes in gene regulation may precede gene duplication.Journal of structural and functional genomics · 2003Review
- Dual roles for Pax-6: a transcriptional repressor of lens fiber cell-specific beta-crystallin genes.Molecular and cellular biology · 1998Article
- Glutathione S-transferase and S-crystallins of cephalopods: evolution from active enzyme to lens-refractive proteins.Journal of molecular evolution · 1995Article
- Pax-6 and lens-specific transcription of the chicken delta 1-crystallin gene.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Molecular pathways to parallel evolution: I. Gene nexuses and their morphological correlates.Journal of molecular evolution · 1994Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous experiments have shown that the minimal promoters required for function of the squid SL20-1 and SL11 crystallin genes in transfected rabbit lens epithelial cells contain an overlapping AP-1/antioxidant responsive element (ARE) upstream of the TATA box. This region resembles the PL-1 and PL-2 elements of the chicken beta B1-crystallin promoter which are essential for promoter function in transfected primary chicken lens epithelial cells. Here we demonstrate by site-directed mutagenesis that the AP-1/ARE sequence is essential for activity of the squid SL20-1 and SL11 promoters in transfected embryonic chicken lens cells and fibroblasts. Promoter activity was higher in transfected lens cells than in fibroblasts. Electrophoretic mobility shift and DNase protection experiments demonstrated the formation of numerous complexes between nuclear proteins of the embryonic chicken lens and the AP-1/ARE sequences of the squid SL20-1 and SL11 crystallin promoters. One of these complexes comigrated and cross-competed with that formed with the PL-1 element of the chicken beta B1-crystallin promoter. This complex formed with nuclear extracts from the lens, heart, brain, and skeletal muscle of embryonic chickens and was eliminated by competition with a consensus AP-1 sequence. The nonfunctional mutant AP-1/ARE sequences did not compete for complex formation. These data raise the intriguing possibility that entirely different, nonhomologous crystallin genes of the chicken and squid have convergently evolved a similar cis-acting regulatory element (AP-1/ARE) for high expression in the lens.
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