ReviewJournal of the Royal College of Physicians of London
Hepatic lipocytes, TIMP-1 and liver fibrosis.
Review in Journal of the Royal College of Physicians of London. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Cirrhosis and Coagulopathy: Mechanisms of Hemostasis Changes in Liver Failure and Their Management.Cureus · 2022Review
- Modulation of mesenchymal stem cells with miR-375 to improve their therapeutic outcome during scar formation.American journal of translational research · 2016Article
- Matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 expression in fibrotic rat liver.World journal of gastroenterology · 2000Article
- Hepatic stellate cells express the low affinity nerve growth factor receptor p75 and undergo apoptosis in response to nerve growth factor stimulation.The American journal of pathology · 2000Article
- Altered balance between matrix metalloproteinases and their inhibitors in experimental biliary fibrosis.The American journal of pathology · 1998Article
- Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Wound healing in the liver with particular reference to stem cells.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1998Review
- Article
- Liver cirrhosis.Postgraduate medical journal · 1998Review
- Activation of matrix metalloproteinase-2 from hepatic stellate cells requires interactions with hepatocytes.The American journal of pathology · 1997Article
Corrections and comments
- Erratum issued
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In progressive liver fibrosis, the rate [corrected] of extracellular collagen deposition exceeds its rate of degradation. Collagen and related proteins are synthesised in the fat-storing liver cells (lipocytes). When injured, these cells proliferate and change into myofibroblast-like cells, secreting even more collagen into the extracellular space. The degradation of collagen is accomplished by metalloproteinases, whose activity is reduced by tissue inhibitors (TIMPs). Injured lipocytes produce an excess of these inhibitors. The final result of lipocyte injury is thus progressive liver fibrosis. There is evidence that TIMPs also play a role in progressive fibrosis in other tissues.
Indexed as
Identifiers
7932316PMC5400988W279241986What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.