ArticleThe Journal of physiology1994
Calcium homeostasis in identified rat gonadotrophs.
Article in The Journal of physiology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 90 citations in OpenAlex.
- Experimental induction and mathematical modeling ofChannels (Austin, Tex.) · 2020Article
- Spontaneous action potentials in retinal horizontal cells of goldfish (Journal of neurophysiology · 2019Article
- Calcium dynamics and regulation in horizontal cells of the vertebrate retina: lessons from teleosts.Journal of neurophysiology · 2017Review
- GnRH-Induced Ca(2+) Signaling Patterns and Gonadotropin Secretion in Pituitary Gonadotrophs. Functional Adaptations to Both Ordinary and Extraordinary Physiological Demands.Frontiers in endocrinology · 2013Review
- Ion channels and signaling in the pituitary gland.Endocrine reviews · 2010Review
- Calcium buffering systems and calcium signaling in aged rat basal forebrain neurons.Aging cell · 2007Review
- Angiotensin II regulates neuronal excitability via phosphatidylinositol 4,5-bisphosphate-dependent modulation of Kv7 (M-type) K+ channels.The Journal of physiology · 2006Article
- A new type of non-Ca2+-buffering Apo(a)-based fluorescent indicator for intraluminal Ca2+ in the endoplasmic reticulum.The Journal of biological chemistry · 2006Article
- Homeostatic compensation maintains Ca2+ signaling functions in Purkinje neurons in the leaner mutant mouse.Cerebellum (London, England) · 2002Review
- Differential regulation of ER Ca2+ uptake and release rates accounts for multiple modes of Ca2+-induced Ca2+ release.The Journal of general physiology · 2002Article
- Endocytosis in identified rat corticotrophs.The Journal of physiology · 2001Article
- Voltage-gated Ca2+ channels and intracellular Ca2+ release regulate exocytosis in identified rat corticotrophs.The Journal of physiology · 2000Article
- Stimulation of Ca(2+)-independent exocytosis in rat pituitary gonadotrophs by G-protein.The Journal of physiology · 2000Article
- Dissection of mitochondrial Ca2+ uptake and release fluxes in situ after depolarization-evoked [Ca2+](i) elevations in sympathetic neurons.The Journal of general physiology · 2000Article
- Differential modulation of the phases of a Ca2+ spike by the store Ca2+-ATPase in human umbilical vein endothelial cells.The Journal of physiology · 1998Article
- alpha-adrenergic stimulation of cytosolic Ca2+ oscillations and exocytosis in identified rat corticotrophs.The Journal of physiology · 1998Article
- Modulation of stimulus-secretion coupling in single rat gonadotrophs.The Journal of physiology · 1997Article
- Mechanism underlying corticotropin-releasing hormone (CRH) triggered cytosolic Ca2+ rise in identified rat corticotrophs.The Journal of physiology · 1997Article
- Generation of action potentials in a mathematical model of corticotrophs.Biophysical journal · 1997Article
- Analytical calculation of intracellular calcium wave characteristics.Biophysical journal · 1997Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
1. Whole-cell voltage clamp was used in conjunction with the fluorescent Ca2+ indicator indo-1 to measure extracellular Ca2+ entry and intracellular Ca2+ concentrations ([Ca2+]i) in rat gonadotrophs identified with the reverse haemolytic plaque assay. 2. Depolarizations to potentials more positive than -40 mV elicited inward Ca2+ current (ICa) and transient elevations of [Ca2+]i. 3. The relationship between [Ca2+]i elevations and Ca2+ entry with different Ca2+ buffer concentrations in the pipette showed that endogenous Ca2+ buffers normally bind approximately 99% of the Ca2+ entering the cell. 4. With [Ca2+]i elevations less than 500 nM, decay of [Ca2+]i could be approximated by an exponential whose time constant increased with the concentration of exogenous Ca2+ buffers. 5. Inhibitors of intracellular Ca(2+)-ATPases, thapsigargin, cyclopiazonic acid (CPA) and 2,5-di-(tert-butyl)-1,4-benzohydroquinone (BHQ), caused [Ca2+]i to rise. Application of BHQ during [Ca2+]i oscillations induced by gonadotrophin-releasing hormone (GnRH) terminated the oscillation in a slowly decaying elevation. BHQ slowed the decay of depolarization-induced [Ca2+]i elevations about 3-fold. 6. Taking into account the Ca2+ buffering properties of the cytoplasm permitted estimation of the fluxes and rate constants for Ca2+ movements in gonadotrophs. The intracellular store is a major determinant of Ca2+ homeostasis in gonadotrophs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.