ArticleThe Journal of experimental medicine1994
Use of recombinant congenic and congenic strains of NOD mice to identify a new insulin-dependent diabetes resistance gene.
Article in The Journal of experimental medicine, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 144 citations in OpenAlex.
- Advancing Animal Models of Human Type 1 Diabetes.Cold Spring Harbor perspectives in medicine · 2024Review
- Syntaxin 4 Enrichment in β-Cells Prevents Conversion to Autoimmune Diabetes in Non-Obese Diabetic (NOD) Mice.Diabetes · 2021Article
- Skeletal Response to Insulin in the Naturally Occurring Type 1 Diabetes Mellitus Mouse Model.JBMR plus · 2021Article
- Article
- Genetic interaction between two insulin-dependent diabetes susceptibility loci, Idd2 and Idd13, in determining immunoregulatory DN T cell proportion.Immunogenetics · 2018Article
- CD40-mediated signalling influences trafficking, T-cell receptor expression, and T-cell pathogenesis, in the NOD model of type 1 diabetes.Immunology · 2017Article
- Donor SIRPα polymorphism modulates the innate immune response to allogeneic grafts.Science immunology · 2017Article
- Early differences in islets from prediabetic NOD mice: combined microarray and proteomic analysis.Diabetologia · 2017Article
- TCR transgenic mice reveal the impact of type 1 diabetes loci on early and late disease checkpoints.Immunology and cell biology · 2016Article
- Type 1 Diabetes Prone NOD Mice Have Diminished Cxcr1 mRNA Expression in Polymorphonuclear Neutrophils and CD4+ T Lymphocytes.PloS one · 2015Article
- Idd13 is involved in determining immunoregulatory DN T-cell number in NOD mice.Genes and immunity · 2014Article
- Molecular pathway alterations in CD4 T-cells of nonobese diabetic (NOD) mice in the preinsulitis phase of autoimmune diabetes.Results in immunology · 2014Article
- Genetic control of murine invariant natural killer T cells maps to multiple type 1 diabetes regions.Genes and immunity · 2013Article
- Genetic and Pharmacologic Models for Type 1 Diabetes.Current protocols in mouse biology · 2013Article
- Subcongenic analyses reveal complex interactions between distal chromosome 4 genes controlling diabetogenic B cells and CD4 T cells in nonobese diabetic mice.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Insulinoma-released exosomes or microparticles are immunostimulatory and can activate autoreactive T cells spontaneously developed in nonobese diabetic mice.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease.Seminars in immunopathology · 2011Review
- The transcription factor MafB antagonizes antiviral responses by blocking recruitment of coactivators to the transcription factor IRF3.Nature immunology · 2010Article
- Article
- Cutting edge: genetic characterization of IFN-producing killer dendritic cells.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Insulin-dependent diabetes mellitus (IDDM) in NOD/Lt mice represents a complex polygenic disease. NOR/Lt is a recombinant congenic strain (RCS) in which limited regions of the NOD/Lt genome have been replaced by genome from the C57BL/KsJ strain. NOR mice are insulitis resistant and diabetes free despite genetic identity with NOD at numerous chromosomal regions containing previously described insulin-dependent diabetes (Idd) genes, including the strongly diabetogenic H2g7 major histocompatibility complex (MHC) haplotype. The present study revealed BKs-derived genome on segments of chromosomes (Chr) 1, 2, 4, 5, 7, 11, 12, and 18, approximating 11.6% of the total NOR genome analyzed. (NOD x NOR)F2 segregation analysis was employed to identify chromosomal regions in NOR containing Idd resistance alleles. IDDM developed in 33% (10/30) of F1 females, and 29.3% (36/123) of F2 females aged to 1 yr. A previously unrecognized diabetes resistance locus (designated Idd13r) strongly protective in homozygous state was identified on NOR Chr 2 in linkage with the Il1 alpha structural gene. The existence of this locus was confirmed by construction of a NOD stock congenic for NOR-derived markers on Chr 2. Our analysis shows the utility of RCS and congenic stocks for the identification and isolation of non-MHC genes with strong antidiabetogenic functions.
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