ArticleThe Journal of experimental medicine1994
Distribution of dominant T cell receptor beta chains in human intestinal mucosa.
Article in The Journal of experimental medicine, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 88 citations in OpenAlex.
- Unique Features of Fish Immune Repertoires: Particularities of Adaptive Immunity Within the Largest Group of Vertebrates.Results and problems in cell differentiation · 2015Review
- Intraepithelial lymphocytes in celiac disease immunopathology.Seminars in immunopathology · 2012Review
- Prevalence of an ulcerative colitis-associated CD8+ T cell receptor beta-chain CDR3-region motif and its association with disease activity.Journal of clinical immunology · 2001Article
- CD4+ and CD8+ clonal T cell expansions indicate a role of antigens in ankylosing spondylitis; a study in HLA-B27+ monozygotic twins.Clinical and experimental immunology · 2001Article
- Identical T cell clones are located within the mouse gut epithelium and lamina propia and circulate in the thoracic duct lymph.The Journal of experimental medicine · 2000Article
- T cell receptor usage in malignant diseases.Springer seminars in immunopathology · 1999Review
- Oligoclonal T cells in human cancer.Medical oncology (Northwood, London, England) · 1998Review
- Intestinal intraepithelial T lymphocytes. Our T cell horizons are expanding.Immunologic research · 1998Review
- Interactions between peripheral blood CD8 T lymphocytes and intestinal epithelial cells (iEC).Clinical and experimental immunology · 1998Article
- Intraepithelial lymphocytes in normal human intestine do not express proteins associated with cytolytic function.The American journal of pathology · 1997Article
- Clinical role for a superantigen in Yersinia pseudotuberculosis infection.The Journal of clinical investigation · 1997Article
- Microbial colonization influences composition and T-cell receptor V beta repertoire of intraepithelial lymphocytes in rat intestine.Immunology · 1996Article
- Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- T cell subsets in normal human epidermis.The American journal of pathology · 1996Article
- Evidence against T-cell development in the adult human intestinal mucosa based upon lack of terminal deoxynucleotidyltransferase expression.Immunology · 1996Article
- Article
- The polymerase chain reaction in the demonstration of monoclonality in T cell lymphomas.Journal of clinical pathology · 1995Article
- The delta T cell receptor repertoire in human colon and peripheral blood is oligoclonal irrespective of V region usage.The Journal of clinical investigation · 1995Article
- Intestinal intraepithelial lymphocytes: the plot thickens.The Journal of experimental medicine · 1994Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The majority of human intestinal intraepithelial lymphocytes (iIELs) are CD8+ T cells that use the T cell receptor (TCR)-alpha/beta. Previous studies have shown that iIELs isolated from segments of small intestine or colon contain one or several dominant alpha/beta T cell clones. It is not known whether these clones expand only locally in response to a particular antigen or whether they are widely distributed throughout the intestine. To address this question, iIELs were purified from near the proximal and distal margins in a series of intestinal resections for noninflammatory diseases. TCR-beta expression was then assessed by semiquantitative polymerase chain reaction amplification, analysis of N-region length, and DNA sequencing. The previously described oligoclonal expansion of iIELs was confirmed in each sample. Identical dominant clones were identified in the proximal and distal samples from most cases, including samples taken from sites as distant as the transverse and sigmoid colon or rectum. Distinct clones were found in only one case with samples from the terminal ileum and transverse colon. These results demonstrate that a relatively small number of widely dispersed T cell clones comprise the majority of cells in the human intestinal mucosa.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.