ArticleThe Journal of experimental medicine1994
Acute inflammation causes epithelial invasion and mucosal destruction in experimental shigellosis.
Article in The Journal of experimental medicine, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
109 citing papers in PubMed, 289 citations in OpenAlex.
- Article
- Sequential invasion of epithelial and immune cells in Shigellosis.bioRxiv : the preprint server for biology · 2026Article
- Host response to bacteria induces a shift towards the enteroendocrine cell lineage in the murine enteroid model.PLoS pathogens · 2026Article
- Shigellosis.Lancet (London, England) · 2025Review
- Determinants of divergentmBio · 2025Article
- Article
- Article
- Toward aInternational journal of molecular sciences · 2023Review
- Functional assays to evaluate antibody-mediated responses againstFrontiers in cellular and infection microbiology · 2023Review
- Article
- Article
- Molecular mechanisms of Shigella effector proteins: a common pathogen among diarrheic pediatric population.Molecular and cellular pediatrics · 2022Review
- Emerging role of protein modification in inflammatory bowel disease.Journal of Zhejiang University. Science. B · 2022Review
- Research in a time of enteroids and organoids: how the human gut model has transformed the study of enteric bacterial pathogens.Gut microbes · 2020Review
- Mechanisms of bacillary dysentery: lessons learnt from infant rabbits.Gut microbes · 2020Review
- Transcytosis subversion by M cell-to-enterocyte spread promotes Shigella flexneri and Listeria monocytogenes intracellular bacterial dissemination.PLoS pathogens · 2020Article
- Genetic variants ofAmerican journal of cancer research · 2020Article
- Host Directed Therapy Against Infection by Boosting Innate Immunity.Frontiers in immunology · 2020Review
- Critical role of bacterial dissemination in an infant rabbit model of bacillary dysentery.Nature communications · 2019Article
- Evaluating Shigella flexneri Pathogenesis in the Human Enteroid Model.Infection and immunity · 2019Article
49 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gram-negative pathogen Shigella flexneri causes bacillary dysentery, an invasive disease of the human colonic mucosa. A major characteristic of the infectious process is the occurrence of an acute inflammatory reaction of mucosal tissues which is generally consequence of primary invasion and destruction of colonic epithelial cells by the pathogen. Confirming in vitro demonstration that S. flexneri is unable to invade the apical pole of colonic cells and that polymorphonuclear (PMN) cells may assist them in reaching the basal side of epithelial cells where they can invade, we have provided here in vivo evidence that S. flexneri enters the epithelial barrier essentially through the dome of lymphoid follicles at the early stage of infection and that subsequent invasion and destruction of the epithelium is primarily due to immigration of leukocytes, particularly PMN that destroy cohesion of the epithelial barrier. These conclusions are based on experiments carried out in infected rabbit ligated intestinal loops, with some animals treated by an anti-CD18 monoclonal antibody that blocked immigration of leukocytes into infected tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.