ArticleThe Journal of clinical investigation1994
Dietary obesity linked to genetic loci on chromosomes 9 and 15 in a polygenic mouse model.
Article in The Journal of clinical investigation, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 153 citations in OpenAlex.
- The Genetic Elements of the Obesity Paradox in Atherosclerosis Identified in an Intercross Between Hyperlipidemic Mouse Strains.International journal of molecular sciences · 2025Article
- High-fat feeding disrupts daily eating behavior rhythms in obesity-prone but not in obesity-resistant male inbred mouse strains.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
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- Systems Genetics of Hepatic Metabolome Reveals Octopamine as a Target for Non-Alcoholic Fatty Liver Disease Treatment.Scientific reports · 2019Article
- Proximate causes for diet-induced obesity in laboratory mice: a case study.European journal of clinical nutrition · 2017Review
- Adiposity QTL Adip20 decomposes into at least four loci when dissected using congenic strains.PloS one · 2017Article
- Defective regulation of POMC precedes hypothalamic inflammation in diet-induced obesity.Scientific reports · 2016Article
- Genetic determinants of atherosclerosis, obesity, and energy balance in consomic mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Article
- Identification of exercise capacity QTL using association mapping in inbred mice.Physiological genomics · 2012Article
- Genetic analysis of atherosclerosis and glucose homeostasis in an intercross between C57BL/6 and BALB/cJ apolipoprotein E-deficient mice.Circulation. Cardiovascular genetics · 2012Article
- Genetic analysis in the Collaborative Cross breeding population.Genome research · 2011Article
- Article
- High-fat diet induces apoptosis of hypothalamic neurons.PloS one · 2009Article
- Genetic influences on growth and body composition in mice: multilocus interactions.International journal of obesity (2005) · 2009Article
- Genotype X diet interactions in mice predisposed to mammary cancer. I. Body weight and fat.Mammalian genome : official journal of the International Mammalian Genome Society · 2008Article
- Quantitative trait loci for individual adipose depot weights in C57BL/6ByJ x 129P3/J F2 mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2006Article
- A locus on mouse Chromosome 9 (Adip5) affects the relative weight of the gonadal but not retroperitoneal adipose depot.Mammalian genome : official journal of the International Mammalian Genome Society · 2006Article
- Article
- Genetic complexity of an obesity QTL ( Fob3) revealed by detailed genetic mapping.Mammalian genome : official journal of the International Mammalian Genome Society · 2004Article
- A large-sample QTL study in mice: II. Body composition.Mammalian genome : official journal of the International Mammalian Genome Society · 2004Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Loci linked to sensitivity to dietary obesity were identified by Quantitative Trait Locus (QTL) analysis of two mapping populations derived from a cross between AKR/J and SWR/J mice. AKR/J mice are sensitive to dietary obesity when fed a high fat diet while SWR/J mice are resistant. Intercrosses between these strains segregate the phenotype of sensitivity to dietary obesity. Using an F2 mapping population of 931 male mice we found significant linkage with a QTL on chromosome 9 (Likelihood of the Odds [LOD] ratio of 4.85) and another QTL on chromosome 15 (LOD = 3.93). The presence of a QTL on chromosome 15 was confirmed in a separate mapping population of 375 male F1 x SWR/J mice (LOD = 3.82). These two loci are designated dietary obese 2 (Do2) and dietary obese 3 (Do3) for the chromosome 9 and 15 loci, respectively. Both of these chromosomal regions contain candidate genes which may contribute to variation in the phenotype. These loci also exert a significant control over individual adipose depot weights.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.