ReviewJournal of anatomy1994
The nature and origins of synovium: experimental approaches to the study of synoviocyte differentiation.
Review in Journal of anatomy, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Multiple strategies, one mission: mesenchymal stromal cell-based mechanisms of action in osteoarthritis.Frontiers in cell and developmental biology · 2026Review
- A Comprehensive Review of Auto- and Allogeneic Chondrocyte Transplantation in Animals and Humans From 1965 to 2025.Cartilage · 2025Article
- Mechanobiology of Hyaluronan: Connecting Biomechanics and Bioactivity in Musculoskeletal Tissues.Annual review of biomedical engineering · 2024Review
- Morphological and Mechanical Characterization of Extracellular Vesicles and Parent Human Synoviocytes under Physiological and Inflammatory Conditions.International journal of molecular sciences · 2022Article
- Article
- Navigating the diverse immune landscapes of psoriatic arthritis.Seminars in immunopathology · 2021Review
- Diversity of Vascular Niches in Bones and Joints During Homeostasis, Ageing, and Diseases.Frontiers in immunology · 2021Review
- Comparison of Hyaluronic Acid Biosynthetic Genes From Different Strains ofBioinformatics and biology insights · 2021Article
- Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies.Bone research · 2018Review
- FOXO1, PXK, PYCARD and SAMD9L are differentially expressed by fibroblast-like cells in equine synovial membrane compared to joint capsule.BMC veterinary research · 2017Article
- Is Synovial Macrophage Activation the Inflammatory Link Between Obesity and Osteoarthritis?Current rheumatology reports · 2016Review
- The inflammatory role of phagocyte apoptotic pathways in rheumatic diseases.Nature reviews. Rheumatology · 2016Review
- Bone marrow contribution to synovial hyperplasia following joint surface injury.Arthritis research & therapy · 2016Article
- Development of synovial membrane in the temporomandibular joint of the human fetus.European journal of histochemistry : EJH · 2015Article
- Cell-based articular cartilage repair: the link between development and regeneration.Osteoarthritis and cartilage · 2015Review
- Utility of arthroscopic guided synovial biopsy in understanding synovial tissue pathology in health and disease states.World journal of orthopedics · 2014Review
- Applied osmotic loading for promoting development of engineered cartilage.Journal of biomechanics · 2013Article
- Reconstruction of an in vitro niche for the transition from intervertebral disc development to nucleus pulposus regeneration.Stem cells and development · 2013Review
- Interleukin-32gamma enhances the production of IL-6 and IL-8 in fibroblast-like synoviocytes via Erk1/2 activation.Journal of clinical immunology · 2010Article
- CD14-negative isolation enhances chondrogenesis in synovial fibroblasts.Tissue engineering. Part A · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synovium is characterised by an intimal layer of cells, now recognised to be a mixture of bone marrow-derived macrophages and specialised fibroblast-like cells. The fibroblast-like cells, or synoviocytes, differ from other fibroblasts in a number of respects, including high activity of uridine diphosphoglucose dehydrogenase (UDPGD) and constitutive expression of VCAM-1. Experiments have been devised to try to establish the factors that control these specialised features. Both high UDPGD activity and VCAM-1 expression can be seen in adventitious or regenerate connective tissue linings tissue under certain circumstances. Mechanical factors may be implicated in the induction of UDPGD activity and VCAM-1 expression, but there is evidence that they are controlled independently. The factors involved in synoviocyte differentiation both in the embryo and under conditions of regeneration or generation ab initio at adventitious sites in the adult require further investigation.
Indexed as
Identifiers
7928638PMC1259957What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.