ArticleJapanese journal of cancer research : Gann1994
Involvement of S100-related calcium-binding protein pEL98 (or mts1) in cell motility and tumor cell invasion.
Article in Japanese journal of cancer research : Gann, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 90 citations in OpenAlex.
- S100A4 contributes to colorectal carcinoma aggressive behavior and to chemoradiotherapy resistance in locally advanced rectal carcinoma.Scientific reports · 2024Article
- S100A4/TCF Complex Transcription Regulation Drives Epithelial-Mesenchymal Transition in Chronic Sinusitis Through Wnt/GSK-3β/β-Catenin Signaling.Frontiers in immunology · 2022Article
- Correlation of two distinct metastasis-associated proteins, MTA1 and S100A4, in angiogenesis for promoting tumor growth.Oncogene · 2019Article
- Enrichment of nuclear S100A4 during G2/M in colorectal cancer cells: possible association with cyclin B1 and centrosomes.Clinical & experimental metastasis · 2015Article
- Myosin II isoform co-assembly and differential regulation in mammalian systems.Experimental cell research · 2015Review
- Efficient inhibition of tumor angiogenesis and growth by a synthetic peptide blocking S100A4-methionine aminopeptidase 2 interaction.Molecular therapy. Methods & clinical development · 2015Article
- Activation of the PI3K/Akt/mTOR/p70S6K pathway is involved in S100A4-induced viability and migration in colorectal cancer cells.International journal of medical sciences · 2014Article
- Silencing of S100A4, a metastasis-associated protein, in endothelial cells inhibits tumor angiogenesis and growth.Angiogenesis · 2014Article
- Structure of the S100A4/myosin-IIA complex.BMC structural biology · 2013Article
- Novel interactions of the TRTK12 peptide with S100 protein family members: specificity and thermodynamic characterization.Biochemistry · 2013Article
- Bay11-7082 inhibits the disintegration of the lymphendothelial barrier triggered by MCF-7 breast cancer spheroids; the role of ICAM-1 and adhesion.British journal of cancer · 2013Article
- Anti-S100A4 antibody suppresses metastasis formation by blocking stroma cell invasion.Neoplasia (New York, N.Y.) · 2012Article
- Article
- NF-κB mediates the 12(S)-HETE-induced endothelial to mesenchymal transition of lymphendothelial cells during the intravasation of breast carcinoma cells.British journal of cancer · 2011Article
- S100A4 regulates macrophage chemotaxis.Molecular biology of the cell · 2010Article
- S100A4 overexpression proves to be independent marker for breast cancer progression.Cancer cell international · 2008Article
- The metastasis-associated protein S100A4 exists in several charged variants suggesting the presence of posttranslational modifications.BMC cancer · 2008Article
- The metastasis associated protein S100A4: role in tumour progression and metastasis.British journal of cancer · 2005Review
- Interaction of metastasis-inducing S100A4 protein in vivo by fluorescence lifetime imaging microscopy.European biophysics journal : EBJ · 2005Article
- S100A4 regulates cell motility and invasion in an in vitro model for breast cancer metastasis.British journal of cancer · 2004Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We examined the relationship between cell motility and the expressions of pEL98 (mts1) mRNA and protein in various murine normal and transformed cells. The expression of pEL98 (mts1) in v-Ha-ras-transformed NIH3T3 cells and in normal rat kidney cells transformed by either v-Ha-ras or v-src was increased over that in the corresponding parental cells at both mRNA and protein levels. The expression in normal rat fibroblasts (3Y1) transformed by v-Ha-ras was also increased compared with that in 3Y1 cells. However, the expression of pEL98 (mts1) in 3Y1 cells transformed by v-src was increased in one clone (src 3Y1-K), but decreased in another clone (src 3Y1-H). The expression level of pEL98 (mts1) correlated well with cell motility, which was examined by measuring cell tracks by phagokinesis. In order to test direct involvement of the pEL98 (mts1) protein in cell motility, src 3Y1-H cells that showed low cell motility were transfected with pEL98 cDNA. The transfectants expressing large amounts of the pEL98 protein showed significantly higher cell motility than src 3Y1-H cells. The expression of pEL98 (mts1) was also found to be correlated with motile and invasive abilities in various clones derived from Lewis lung carcinoma. These results suggest that the pEL98 (mts1) protein plays a role in regulating cell motility and tumor cell invasiveness.
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