ArticleInfection and immunity1994
Vaccination with Brucella abortus rough mutant RB51 protects BALB/c mice against virulent strains of Brucella abortus, Brucella melitensis, and Brucella ovis.
Article in Infection and immunity, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 112 citations in OpenAlex.
- Meta-Analysis and Advancement of Brucellosis Vaccinology.PloS one · 2016Pooled it
- Effect of vaccination with Brucella abortus strain RB51 on heifers and pregnant cattle.Veterinary research communications · 2000Trial
- Immune biomarkers, profiles, and responses: a vaccine ontology perspective.Journal of biomedical semantics · 2026Article
- Immunoinformatic design of a multivalent vaccine againstFrontiers in immunology · 2024Article
- Live mucosal vaccination stimulates potent protectionFrontiers in immunology · 2022Article
- When the Going Gets Rough: The Significance ofFrontiers in microbiology · 2021Review
- Development of attenuated live vaccine candidates against swine brucellosis in a non-zoonotic B. suis biovar 2 background.Veterinary research · 2020Article
- Vaxign-ML: supervised machine learning reverse vaccinology model for improved prediction of bacterial protective antigens.Bioinformatics (Oxford, England) · 2020Article
- Brucella abortus ΔrpoE1 confers protective immunity against wild type challenge in a mouse model of brucellosis.Vaccine · 2016Article
- Vaxar: A Web-Based Database of Laboratory Animal Responses to Vaccinations and Its Application in the Meta-Analysis of Different Animal Responses to Tuberculosis Vaccinations.Comparative medicine · 2016Article
- Characterization and protective property of Brucella abortus cydC and looP mutants.Clinical and vaccine immunology : CVI · 2014Article
- Ontology representation and analysis of vaccine formulation and administration and their effects on vaccine immune responses.Journal of biomedical semantics · 2012Article
- What have we learned from brucellosis in the mouse model?Veterinary research · 2012Review
- Caspase-2-dependent dendritic cell death, maturation, and priming of T cells in response to Brucella abortus infection.PloS one · 2012Article
- Efficacy of strain RB51 vaccine in protecting infection and vertical transmission against Brucella abortus in Sprague-Dawley rats.Journal of veterinary science · 2009Article
- Interaction of Brucella suis and Brucella abortus rough strains with human dendritic cells.Infection and immunity · 2007Article
- Deletion of znuA virulence factor attenuates Brucella abortus and confers protection against wild-type challenge.Infection and immunity · 2006Article
- Evaluation of protection afforded by Brucella abortus and Brucella melitensis unmarked deletion mutants exhibiting different rates of clearance in BALB/c mice.Infection and immunity · 2006Article
- Protective properties of rifampin-resistant rough mutants of Brucella melitensis.Infection and immunity · 2005Article
- Oral vaccination with Brucella melitensis WR201 protects mice against intranasal challenge with virulent Brucella melitensis 16M.Infection and immunity · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vaccination of BALB/c mice with live Brucella abortus RB51, a stable rough mutant, produced protection against challenge with virulent strains of Brucella abortus, Brucella melitensis, and Brucella ovis. Passive-transfer experiments indicated that vaccinated mice were protected against B. abortus 2308 through cell-mediated immunity, against B. ovis PA through humoral immunity, and against B. melitensis 16M through both forms of immunity. Live bacteria were required for the induction of protective cell-mediated immunity; vaccination with whole killed cells of strain RB51 failed to protect mice against B. abortus 2308 despite development of good delayed-type hypersensitivity reactions. Protective antibodies against the heterologous species were generated in vaccinated mice primarily through anamnestic responses following challenge infections. Growth of the antigenically unrelated bacterium Listeria monocytogenes in the spleens of vaccinated mice indicated that nonspecific killing by residual activated macrophages contributed minimally to protection. These results encourage the continued investigation of strain RB51 as an alternative vaccine against heterologous Brucella species. However, its usefulness against B. ovis would be limited if, as suggested here, epitopes critical for protective cell-mediated immunity are not shared between B. abortus and B. ovis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.