ArticleInfection and immunity1994
Effects of a Porphyromonas gingivalis infection on inflammatory mediator response and pregnancy outcome in hamsters.
Article in Infection and immunity, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 212 citations in OpenAlex.
- [Pathways and Mechanisms of Periodontitis Contributing to Adverse Pregnancy Outcomes].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2023Pooled it
- The potential association between gingival crevicular fluid inflammatory mediators and adverse pregnancy outcomes: a systematic review.Clinical oral investigations · 2013Pooled it
- Periodontal therapy and risk for adverse pregnancy outcomes.Clinical oral investigations · 2011Trial
- Serum inflammatory mediators in pregnancy: changes after periodontal treatment and association with pregnancy outcomes.Journal of periodontology · 2009Trial
- Knowledge, awareness, and attitudes of medical professionals toward the periodontal-systemic disease relationship: a cross-sectional study.Frontiers in oral health · 2026Article
- Placental and maternal microbiome adaptations in a preeclamptic-like mouse model.Frontiers in microbiomes · 2026Article
- Periodontal health and pregnancy outcomes: Time to deliver.Acta obstetricia et gynecologica Scandinavica · 2023Article
- The Association of Periodontal Disease with Low Birth Weight Infants: A Case Control Study.Maternal and child health journal · 2023Article
- IL-1β and TNF-α play an important role in modulating the risk of periodontitis and Alzheimer's disease.Journal of neuroinflammation · 2023Article
- Psychologically informed oral health interventions in pregnancy and type 2 diabetes: a scoping review protocol.BMJ open · 2022Article
- Psychologically informed oral health interventions in pregnancy and type 2 diabetes: A scoping review.Frontiers in oral health · 2022Article
- Maternal microbiome in preeclampsia pathophysiology and implications on offspring health.Physiological reports · 2021Review
- Quantitative analysis of key periodontopathic bacteria in gestational diabetic and non-diabetic women.Journal of diabetes and metabolic disorders · 2019Article
- Fetal Weight Outcomes in C57BL/6J and C57BL/6NCrl Mice after Oral Colonization withInfection and immunity · 2019Article
- Review
- Systemic effects of periodontitis: lessons learned from research on atherosclerotic vascular disease and adverse pregnancy outcomes.International dental journal · 2015Review
- Increased periodontal inflammation in women with preterm premature rupture of membranes.Clinical oral investigations · 2015Article
- Association of Periodontal Disease and Pre-term Low Birth Weight Infants.Journal of obstetrics and gynaecology of India · 2015Article
- Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
This study examines the effects of various localized, nondissemination challenges of Porphyromonas gingivalis on inflammatory mediator production and pregnancy outcome in the golden hamster. Live or heat-killed (HK) organisms were inoculated into a previously implanted subcutaneous tissue chamber on the 8th day of gestation to determine the effects on fetal weight, viability, and resorption. In one group of animals, HK organisms were inoculated prior to mating to determine the effects of previous exposure on day-8 gestational challenges. Chamber contents were assayed at 1 and 5 days after challenge for prostaglandin E2 (PGE2) and tumor necrosis factor alpha (TNF-alpha). All P. gingivalis challenges caused a significant increase in chamber PGE2 and TNF-alpha at P < 0.01 in the following order of potency: HK < Live < HK+Live. For example, following the HK+Live challenge, PGE2 levels increased from 4.7 pg/ml at baseline to 362 pg/ml at day 5 and TNF-alpha increased from 26.4 pg/ml to 724 pg/ml at day 5. The same order of potency of the various challenges was maintained with regard to the toxic effects of P. gingivalis on pregnancy outcome. For the HK+Live challenge, fetal weight was decreased 24%; embryolethality increased to 26.5% and the percent fetal resorption increased to 10.6% compared with control animal levels. There was a statistically significant association between increasing levels of both PGE2 and TNF-alpha and fetal growth retardation and embryolethality at P < 0.001. These data suggest that infections with gram-negative periodontal pathogens can elicit adverse pregnancy outcomes and that the levels of PGE2 and TNF-alpha produced as a result of challenge are associated with the severity of fetal effect.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.