ArticleInfection and immunity1994
Virulence properties and attaching-effacing activity of Escherichia coli O45 from swine postweaning diarrhea.
Article in Infection and immunity, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 94 citations in OpenAlex.
- A foodborne outbreak caused by atypical enteropathogenicApplied and environmental microbiology · 2025Article
- O-Serogroups and Pathovirotypes ofVeterinary sciences · 2021Article
- Genome Characterization ofFrontiers in veterinary science · 2020Article
- Swine Enteric Colibacillosis in Spain: Pathogenic Potential ofFrontiers in microbiology · 2018Article
- High-throughput microfluidic method to study biofilm formation and host-pathogen interactions in pathogenic Escherichia coli.Applied and environmental microbiology · 2015Article
- Role of F1C fimbriae, flagella, and secreted bacterial components in the inhibitory effect of probiotic Escherichia coli Nissle 1917 on atypical enteropathogenic E. coli infection.Infection and immunity · 2014Article
- Prevalence of the paa gene (porcine attaching and effacing associated) in porcine enteropathogenic Escherichia coli (PEPEC) associated with postweaning diarrhea in south Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2013Article
- Porcine E. coli: virulence-associated genes, resistance genes and adhesion and probiotic activity tested by a new screening method.PloS one · 2013Article
- Two distinct groups of porcine enteropathogenic Escherichia coli strains of serogroup O45 are revealed by comparative genomic hybridization and virulence gene microarray.BMC genomics · 2009Article
- Serotypes, virulence genes, and PFGE profiles of Escherichia coli isolated from pigs with postweaning diarrhoea in Slovakia.BMC veterinary research · 2006Article
- Interaction of enteropathogenic and Shiga toxin-producing Escherichia coli and porcine intestinal mucosa: role of intimin and Tir in adherence.Infection and immunity · 2005Article
- Host immune status influences the development of attaching and effacing lesions in weaned pigs.Infection and immunity · 2005Article
- Attaching-effacing bacteria in animals.Journal of comparative pathology · 2005Review
- Genotyping of fimbrial adhesins in Escherichia coli strains isolated from Slovak piglets suffering from diarrhea.Folia microbiologica · 2004Article
- Transduction of porcine enteropathogenic Escherichia coli with a derivative of a shiga toxin 2-encoding bacteriophage in a porcine ligated ileal loop system.Applied and environmental microbiology · 2003Article
- Characterization of the novel factor paa involved in the early steps of the adhesion mechanism of attaching and effacing Escherichia coli.Infection and immunity · 2003Article
- A mosaic pathogenicity island made up of the locus of enterocyte effacement and a pathogenicity island of Escherichia coli O157:H7 is frequently present in attaching and effacing E. coli.Infection and immunity · 2003Article
- Vaccination of pregnant dams with intimin(O157) protects suckling piglets from Escherichia coli O157:H7 infection.Infection and immunity · 2002Article
- Complete nucleotide sequence and analysis of the locus of enterocyte Effacement from rabbit diarrheagenic Escherichia coli RDEC-1.Infection and immunity · 2001Article
- Role of tir and intimin in the virulence of rabbit enteropathogenic Escherichia coli serotype O103:H2.Infection and immunity · 2000Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Escherichia coli O45 isolates associated with swine postweaning diarrhea in Québec were characterized with respect to virulence determinants genetically and investigated for their attaching and effacing (A/E) activities by experimental inoculation of gnotobiotic piglets and by the HEp-2 cell adherence assay. All of 32 isolates tested were negative for enterotoxigenic and verotoxigenic E. coli virulence determinants, heat-labile enterotoxin (LT), heat-stable enterotoxins (STap, STb), verotoxins (VT1, VT2), and F4 (K88), F5 (K99), F6 (987P), and F41, except one STb-positive and two F4-positive isolates. A total of 25 isolates hybridized with an EaeA probe, and 11 hybridized with an enteropathogenic E. coli adherence factor (EAF) probe. None of 32 isolates hybridized with a bundle-forming pilus (BFP) probe. The EAF, EaeA, and BFP factors have been associated with human enteropathogenic E. coli strains. A total of 10 of 12 eaeA-positive porcine O45 isolates induced A/E lesions characterized by intimate adherence of bacteria to the intestinal epithelial cell membrane with effacement of the microvilli, similar to those of human attaching-effacing E. coli. However, A/E lesions were not observed in the piglets inoculated with any one of three eaeA-negative O45 isolates. All E. coli O45 isolates were non-adherent to HEp-2 cells. Thus, we have demonstrated the production of typical A/E lesions by nonenterotoxigenic E. coli O45 isolates from swine postweaning diarrhea. The results indicate the significance of the eaeA gene in A/E activities of these isolates and suggest that EAF and BFP are not involved in O45 E. coli infection of weaning piglets.
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