ArticleImmunology1994
The role of the carbohydrate chains in complement (C3) fixation by solid-phase-bound human IgA.
Article in Immunology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 64 citations in OpenAlex.
- Advances in IgA glycosylation and its correlation with diseases.Frontiers in chemistry · 2022Review
- Immunoglobulin A Glycosylation and Its Role in Disease.Experientia supplementum (2012) · 2021Article
- Elevated free secretory component in early rheumatoid arthritis and prior to arthritis development in patients at increased risk.Rheumatology (Oxford, England) · 2020Observational
- Oral pre-administration of Purslane polysaccharides enhance immune responses to inactivated foot-and-mouth disease vaccine in mice.BMC veterinary research · 2019Article
- Glycosylation of Human IgA Directly Inhibits Influenza A and Other Sialic-Acid-Binding Viruses.Cell reports · 2018Article
- C4d deposits in IgA nephropathy: where does complement activation come from?Pediatric nephrology (Berlin, Germany) · 2017Article
- Pneumococcal IgA1 protease subverts specific protection by human IgA1.Mucosal immunology · 2014Article
- Determination of severity of murine IgA nephropathy by glomerular complement activation by aberrantly glycosylated IgA and immune complexes.The American journal of pathology · 2012Article
- Gastrointestinal manifestations of Henoch-Schonlein Purpura.Digestive diseases and sciences · 2008Review
- Impact of the molecular form of immunoglobulin A on functional activity in defense against Streptococcus pneumoniae.Infection and immunity · 2007Article
- Progress in molecular and genetic studies of IgA nephropathy.Journal of clinical immunology · 2001Review
- Circulating immune complexes in IgA nephropathy consist of IgA1 with galactose-deficient hinge region and antiglycan antibodies.The Journal of clinical investigation · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In contrast to antigen-antibody complexes containing native human IgA, solid-phase-deposited IgA activates the alternative complement pathway and binds C3b. To investigate the role of carbohydrate chains in this, various human IgA preparations were treated with neuraminidase alone or together with N-glycanase or O-glycanase, or with mixed glycosidases from the oral bacterium, Streptococcus mitis. Depletion of oligosaccharides was determined by carbohydrate analysis. Removal of sialic acid and N-linked glycan chains greatly increased the C3b-fixing properties of normal serum IgA1 and IgA2. Myeloma IgA1 and IgA2 proteins and secretory IgA had higher C3b-binding activity than normal serum IgA, and this was further increased by removal of sialic acid and N-linked glycans. Fc alpha and Fc alpha-SC fragments of myeloma and secretory IgA1, respectively, but not Fab alpha fragments, obtained by cleavage with bacterial IgA1 proteases and also free secretory component, fixed C3b by the alternative pathway.
Indexed as
Identifiers
7927504PMC1414811W187561596What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.