Evidence map›Paper›PMID 7927340›Full record

ArticleHuman genetics1994

Linkage mapping of the tumor necrosis factor receptor 2 (TNFR2) gene to 1p36.2 using the single-strand conformation polymorphism technique.

B A Kaufman, P S White, T Steinbrueck, H Donis-Keller, G M Brodeur

Abstract read
PubMed Publisher
In one paragraph

Article in Human genetics, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. International journal of molecular sciences · 2024
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

B A KaufmanDepartment of Neurological Surgery, Washington University School of Medicine, Saint Louis, MO 63110.
P S White
T Steinbrueck
H Donis-Keller
G M Brodeur
Washington University in St. Louis · USSt. Louis Children's Hospital · US

Funding

MOLECULAR GENETIC ANALYSIS OF NEUROBLASTOMAR01CA039771 · NCI · WASHINGTON UNIVERSITY · PI BRODEUR, GARRETT M · 1985 to 2013
$4.2M
A COMPLETE GENETIC LINKAGE MAP OF THE HUMAN GENOMER01HG000304 · NHGRI · WASHINGTON UNIVERSITY · PI DONIS-KELLER, HELEN R · 1990 to 1991
–
NCI NIH HHS R01-CA39771NHGRI NIH HHS R01-HG00304
6 · The paper itself

Abstract

We identified two informative polymorphisms in the transcribed 3' untranslated region of the tumor necrosis factor receptor 2 (TNFR2) gene using the polymerase chain reaction (PCR) with the single-strand conformation polymorphism (SSCP) technique. These polymorphisms demonstrated Mendelian inheritance and were useful for linkage analysis. TNFR2 was very closely linked to the pronatriodilatin gene (PND), and the TNFR2 SSCP polymorphisms were much more informative than the restriction fragment length polymorphisms currently available for the PND locus. In addition, we have demonstrated that genotyping could be performed with DNA obtained from paraffin-embedded tissue.

Indexed as

Chromosomes, Human, Pair 1Genetic LinkagePolymorphism, Single-Stranded ConformationalBase SequenceChromosome MappingHumansMolecular Sequence DataParaffin EmbeddingPolymerase Chain ReactionReceptors, Tumor Necrosis FactorReceptors, Tumor Necrosis Factor

Identifiers

PMID7927340
OpenAlexW2007834872

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.