ArticleHuman genetics1994
Nondisjunction of human acrocentric chromosomes: studies of 432 trisomic fetuses and liveborns.
Article in Human genetics, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 116 citations in OpenAlex.
- Influence of parental age on chromosomal abnormalities in PGT-A embryos: exponentially increasing in the mother and completely null in the father.Journal of assisted reproduction and genetics · 2025Article
- Aberrant landscapes of maternal meiotic crossovers contribute to aneuploidies in human embryos.Genome research · 2024Article
- Advanced Paternal Age and Future Generations.Frontiers in endocrinology · 2022Review
- Advanced paternal age does not affect embryo aneuploidy following blastocyst biopsy in egg donor cycles.Journal of assisted reproduction and genetics · 2019Article
- Disentangling the roles of maternal and paternal age on birth prevalence of down syndrome and other chromosomal disorders using a Bayesian modeling approach.BMC medical research methodology · 2019Article
- Generation of meiomaps of genome-wide recombination and chromosome segregation in human oocytes.Nature protocols · 2016Article
- Genome-wide maps of recombination and chromosome segregation in human oocytes and embryos show selection for maternal recombination rates.Nature genetics · 2015Article
- Male biological clock: a critical analysis of advanced paternal age.Fertility and sterility · 2015Review
- Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring.Reproductive biology and endocrinology : RB&E · 2015Review
- An unexpected finding: younger fathers have a higher risk for offspring with chromosomal aneuploidies.European journal of human genetics : EJHG · 2015Article
- Development of patients with 47,XX,+13/45,X mosaics: case report and review of the literature.European journal of pediatrics · 2014Review
- Evidence for paternal age-related alterations in meiotic chromosome dynamics in the mouse.Genetics · 2014Article
- Advanced paternal age and reproductive outcome.Asian journal of andrology · 2012Review
- The use of foetal ovarian stromal cell culture for cytogenetic diagnosis. Stromal ovarian culture cytogenetic diagnosis.Cytotechnology · 2003Article
- Maternal folate polymorphisms and the etiology of human nondisjunction.American journal of human genetics · 2001Article
- The development of colon innervation in trisomy 16 mice and Hirschsprung's disease.World journal of gastroenterology · 2001Article
- The effects of age and abnormal sperm count on the nondisjunction of spermatozoa.Journal of assisted reproduction and genetics · 2000Article
- Recurrent Trisomies: Chance or Inherited Predisposition?Journal of genetic counseling · 1999Article
- Studies of non-disjunction in trisomies 2, 7, 15, and 22: does the parental origin of trisomy influence placental morphology?Journal of medical genetics · 1998Article
- Meiotic origin of trisomy in confined placental mosaicism is correlated with presence of fetal uniparental disomy, high levels of trisomy in trophoblast, and increased risk of fetal intrauterine growth restriction.American journal of human genetics · 1997Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
The present report summarizes molecular studies on the parent and meiotic stage of origin of the additional chromosome in 432 fetuses or liveborns with an additional chromosome 13, 14, 15, 21, or 22. Our studies suggest that there is little variation in the origin of nondisjunction among the five acrocentric trisomies and that there is no association between the origin of nondisjunction and the likelihood of survival to term of the trisomic conceptus. The proportion of cases of paternal origin was similar among the five trisomies: 12% for trisomy 13, 17% for trisomy 14, 12% for trisomy 15, 9% for trisomy 21, and 11% for trisomy 22. The stage of nondisjunction was also similar among the five trisomies, with the majority of cases of maternal origin being due to nondisjunction at meiosis I, whereas for paternally derived cases, nondisjunction occurred primarily at meiosis II.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.