ArticleHuman genetics1994
A fluorescent in situ hybridization analysis of X chromosome pairing in early human female meiosis.
Article in Human genetics, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 37 citations in OpenAlex.
- Global gene expression in the human fetal testis and ovary.Biology of reproduction · 2009Article
- The use of foetal ovarian stromal cell culture for cytogenetic diagnosis. Stromal ovarian culture cytogenetic diagnosis.Cytotechnology · 2003Article
- Asynchronous chromosome pairing in male meiosis of the rat (Rattus norvegicus).Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2001Article
- Human female meiosis: new insights into an error-prone process.American journal of human genetics · 1997Review
- Combined immunocytogenetic and molecular cytogenetic analysis of meiosis I human spermatocytes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 1996Article
- Centromere and telomere movements during early meiotic prophase of mouse and man are associated with the onset of chromosome pairing.The Journal of cell biology · 1996Article
- The effect of Y-chromosome alpha-satellite array length on the rate of sex chromosome disomy in human sperm.Human genetics · 1996Article
- Recombination and maternal age-dependent nondisjunction: molecular studies of trisomy 16.American journal of human genetics · 1995Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Fluorescent in situ hybridization (FISH) utilizating an X chromosome whole library probe was used directly to assess the rate of aneuploidy and pairing behavior of the X chromosome in human female meiosis. Over 3000 meiotic cells obtained from fetal ovaries (gestational age 13-22 weeks) were scored for meiotic stage and evaluated for pairing abnormalities. No pairing anomalies were observed in 832 pachytenes. Twenty-two percent (88/398) of cells in zygotene were partially paired, but nonhomologous pairings could not be identified. One aneuploid preleptotene oocyte, presumably from mitotic nondisjunction was detected. To our knowledge, this is the first report of the use of FISH utilizing whole chromosome probes to evaluate the pairing behavior of chromosomes in human female meiosis. The application of this technique to study the relationship between nondisjunction and chromosome pairing behavior in maternal-age-related aneuploidy is discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.