ArticleThe EMBO journal1994
Cdc16p, Cdc23p and Cdc27p form a complex essential for mitosis.
Article in The EMBO journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers.
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Who cites it
98 citing papers in PubMed.
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- O-linked β-N-acetylglucosamine (O-GlcNAc) modification: Emerging pathogenesis and a therapeutic target of diabetic nephropathy.Diabetic medicine : a journal of the British Diabetic Association · 2025Review
- A comparative study of the cryo-EM structures ofeLife · 2024Article
- Gene Expression Analysis of Yeast Strains with a Nonsense Mutation in the eRF3-Coding Gene Highlights Possible Mechanisms of Adaptation.International journal of molecular sciences · 2024Article
- An intellectual disability syndrome with single-nucleotide variants in O-GlcNAc transferase.European journal of human genetics : EJHG · 2020Review
- Promotion of Hyperthermic-Induced rDNA Hypercondensation inGenetics · 2020Article
- Pex14p Phosphorylation Modulates Import of Citrate Synthase 2 Into Peroxisomes inFrontiers in cell and developmental biology · 2020Article
- APC/C: current understanding and future perspectives.F1000Research · 2019Review
- Activating the Anaphase Promoting Complex to Enhance Genomic Stability and Prolong Lifespan.International journal of molecular sciences · 2018Review
- Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C).Open biology · 2017Review
- Structural Insight into Anaphase Promoting Complex 3 Structure and Docking with a Natural Inhibitory Compound.Advanced biomedical research · 2017Article
- Data collection with a tailored X-ray beam size at 2.69 Å wavelength (4.6 keV): sulfur SAD phasing of Cdc23(Nterm).Acta crystallographica. Section D, Structural biology · 2016Article
- Yeast Elongator protein Elp1p does not undergo proteolytic processing in exponentially growing cells.MicrobiologyOpen · 2015Article
- Structure of an APC3-APC16 complex: insights into assembly of the anaphase-promoting complex/cyclosome.Journal of molecular biology · 2015Article
- Phosphorylation and dephosphorylation regulate APC/C(Cdh1) substrate degradation.Cell cycle (Georgetown, Tex.) · 2015Article
- The four canonical tpr subunits of human APC/C form related homo-dimeric structures and stack in parallel to form a TPR suprahelix.Journal of molecular biology · 2013Article
- Mutually dependent degradation of Ama1p and Cdc20p terminates APC/C ubiquitin ligase activity at the completion of meiotic development in yeast.Cell division · 2013Article
- A Wee1 checkpoint inhibits anaphase onset.The Journal of cell biology · 2013Article
- Article
- Structural insights into anaphase-promoting complex function and mechanism.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Review
38 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
Abstract
Cdc16p, Cdc23p and Cdc27p are all essential proteins required for cell cycle progression through mitosis in Saccharomyces cerevisiae. All three proteins contain multiple tandemly repeated 34 amino acid tetratricopeptide repeats (TPRs). Using two independent assays, two-hybrid analysis in vivo and co-immunoprecipitation in vitro, we demonstrate that Cdc16p, Cdc23p and Cdc27p self associate and interact with one another to form a macromolecular complex. A temperature sensitive mutation in the most highly conserved TPR domain of Cdc27p results in a greatly reduced ability to interact with Cdc23p, but has no effect on interactions with wild-type Cdc27p or Cdc16p. The specificity of this effect indicates that TPRs can mediate protein-protein interactions and that this mutation may define an essential interaction for cell cycle progression in yeast. The conservation of at least two of the three proteins from yeast to man suggests that this protein complex is essential for mitosis in a wide range of eukaryotes.
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