ArticleThe EMBO journal1994
Thyroid abnormalities and hepatocellular carcinoma in mice transgenic for v-erbA.
Article in The EMBO journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 83 citations in OpenAlex.
- Actions of thyroid hormones and thyromimetics on the liver.Nature reviews. Gastroenterology & hepatology · 2025Review
- Impact of Hypothyroidism on Patients with Hepatocellular Carcinoma Undergoing Liver Transplantation.International journal of general medicine · 2021Article
- Thyroid hormones in diabetes, cancer, and aging.Aging cell · 2020Review
- Roles of Thyroid Hormone-Associated microRNAs Affecting Oxidative Stress in Human Hepatocellular Carcinoma.International journal of molecular sciences · 2019Review
- Molecular Functions of Thyroid Hormone Signaling in Regulation of Cancer Progression and Anti-Apoptosis.International journal of molecular sciences · 2019Review
- The Role of Thyroid Hormones in Hepatocyte Proliferation and Liver Cancer.Frontiers in endocrinology · 2019Review
- Analysis of Thyroid Tumorigenesis in Xenograft Mouse Model.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Thyroid hormone protects hepatocytes from HBx-induced carcinogenesis by enhancing mitochondrial turnover.Oncogene · 2017Article
- Thyroid hormone suppresses hepatocarcinogenesis via DAPK2 and SQSTM1-dependent selective autophagy.Autophagy · 2016Article
- The role of thyroid hormone signaling in the prevention of digestive system cancers.International journal of molecular sciences · 2013Review
- Thyroid hormone receptors and cancer.Biochimica et biophysica acta · 2013Review
- Thyroid hormone actions in liver cancer.Cellular and molecular life sciences : CMLS · 2013Review
- Molecular functions of thyroid hormones and their clinical significance in liver-related diseases.BioMed research international · 2013Review
- Thyroid hormone receptors promote metastasis of human hepatoma cells via regulation of TRAIL.Cell death and differentiation · 2012Article
- Mutation of thyroid hormone receptor-β in mice predisposes to the development of mammary tumors.Oncogene · 2011Article
- The effect of oncoprotein v-erbA on thyroid hormone-regulated genes in hepatocytes and their potential role in hepatocellular carcinoma.Molecular biology reports · 2011Article
- Thyroid hormone receptor mutations in cancer and resistance to thyroid hormone: perspective and prognosis.Journal of thyroid research · 2011Article
- Thyroid hormone receptor mutants implicated in human hepatocellular carcinoma display an altered target gene repertoire.Oncogene · 2009Article
- Thyroid hormone receptor mutations found in renal clear cell carcinomas alter corepressor release and reveal helix 12 as key determinant of corepressor specificity.Molecular endocrinology (Baltimore, Md.) · 2009Article
- Novel oncogenic actions of TRbeta mutants in tumorigenesis.IUBMB life · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The v-erbA oncogene consists of an avian retroviral gag gene fused to a mutated thyroid hormone receptor. To define better its role as an oncogene in mammals and its ability to function as a dominant negative transcription factor, transgenic mice expressing v-erbA ubiquitously were generated. The effects of v-erbA are pleiotropic, tissue-specific and dose dependent. Mice have breeding disorders, abnormal behavior, reduced adipose tissue, hypothyroidism with inappropriate TSH response, and enlarged seminal vesicles. This provides an animal model consistent with the proposal that v-ErbA functions as a dominant negative receptor by transcriptional interference or squelching of normal receptors or associated proteins. Finally, male animals develop hepatocellular carcinoma, demonstrating that v-erbA can promote neoplasia in mammals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.