ArticleClinical & experimental metastasis1994
The role of extracellular matrix in human astrocytoma migration and proliferation studied in a microliter scale assay.
Article in Clinical & experimental metastasis, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 121 citations in OpenAlex.
- Dexamethasone-mediated inhibition of Glioblastoma neurosphere dispersal in an ex vivo organotypic neural assay.PloS one · 2017Article
- Epithelial cell migration requires the interaction between the vimentin and keratin intermediate filaments.Scientific reports · 2016Article
- Glioma Cell Invasion is Significantly Enhanced in Composite Hydrogel Matrices Composed of Chondroitin 4- and 4,6-Sulfated Glycosaminoglycans.Journal of materials chemistry. B · 2016Article
- Radial mobility and cytotoxic function of retroviral replicating vector transduced, non-adherent alloresponsive T lymphocytes.Journal of visualized experiments : JoVE · 2015Article
- Role of tenascins in the ECM of gliomas.Cell adhesion & migration · 2015Review
- Article
- Toward 3D biomimetic models to understand the behavior of glioblastoma multiforme cells.Tissue engineering. Part B, Reviews · 2014Review
- The Src homology 3 domain-containing guanine nucleotide exchange factor is overexpressed in high-grade gliomas and promotes tumor necrosis factor-like weak inducer of apoptosis-fibroblast growth factor-inducible 14-induced cell migration and invasion via tumor necrosis factor receptor-associated factor 2.The Journal of biological chemistry · 2013Article
- Reciprocal activation of transcription factors underlies the dichotomy between proliferation and invasion of glioma cells.PloS one · 2013Article
- Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells.Molecular cancer research : MCR · 2012Article
- Galectin-1, a gene preferentially expressed at the tumor margin, promotes glioblastoma cell invasion.Molecular cancer · 2012Article
- miRNA expression profiling in migrating glioblastoma cells: regulation of cell migration and invasion by miR-23b via targeting of Pyk2.PloS one · 2012Article
- Hydrodynamic cellular volume changes enable glioma cell invasion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Post-translational regulation of cathepsin B, but not of other cysteine cathepsins, contributes to increased glioblastoma cell invasiveness in vitro.Pathology oncology research : POR · 2009Article
- The role of the membrane cytoskeleton cross-linker ezrin in medulloblastoma cells.Neuro-oncology · 2009Article
- NHERF-1: modulator of glioblastoma cell migration and invasion.Neoplasia (New York, N.Y.) · 2009Article
- The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma.The American journal of pathology · 2008Article
- The role of fascin in the migration and invasiveness of malignant glioma cells.Neoplasia (New York, N.Y.) · 2008Article
- Glioma cells on the run - the migratory transcriptome of 10 human glioma cell lines.BMC genomics · 2008Article
- The p75 neurotrophin receptor is a central regulator of glioma invasion.PLoS biology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Ligands in the extracellular matrix (ECM) are known to mediate migration of normal as well as tumor cells via adhesion molecules such as the integrin receptor family. We develop a microliter scale (15-20 microliters total volume) monolayer migration assay to investigate the ability of astrocytoma cells to disperse on surfaces coated with purified human ECM protein ligands. In this system the rate of radial migration of the cell population was constant over time. For human astrocytoma cell lines U-251 and SF-767, laminin and collagen type IV supported a migratory phenotype; fibronectin and vitronectin only minimally supported migration. The different ECM proteins also influenced growth rate: cells on laminin and collagen had a protracted lag phase. Furthermore, migrating cells seeded on laminin or collagen showed a lower labeling index than did stationary cells in the central, crowded region on the same substrate. This micro-scale migration assay should enable detailed molecular and biochemical studies of the determinants of migration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.