ArticleClinical and experimental immunology1994
Increase of circulating gamma/delta T lymphocytes in the peripheral blood of patients affected by active inflammatory bowel disease.
Article in Clinical and experimental immunology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Immune Activation in Primary Sclerosing Cholangitis: A Systematic Review and Comparative Analysis With Inflammatory Bowel Diseases.United European gastroenterology journal · 2025Pooled it
- Similarities and Differences in the Immune Characteristics of Intestinal Gamma Delta T Cells From Patients With Crohn's Disease and Ulcerative Colitis and Their Correlation With Disease Activity.Immunity, inflammation and disease · 2025Article
- Article
- High-dimensional profiling reveals Tc17 cell enrichment in active Crohn's disease and identifies a potentially targetable signature.Nature communications · 2022Article
- IL-17 and limits of success.Cellular immunology · 2019Review
- A rare case of hepatosplenic gamma-delta T-cell lymphoma and secondary hemophagocytic lymphohistiocytosis.Clinical case reports · 2019Article
- Human Vδ1Frontiers in immunology · 2019Review
- Tissue Adaptations of Memory and Tissue-Resident Gamma Delta T Cells.Frontiers in immunology · 2018Review
- Immunophenotype of Peripheral Blood Lymphocytes in Dogs with Inflammatory Bowel Disease.Journal of veterinary internal medicine · 2017Article
- γδ T Cells Coexpressing Gut Homing α4β7 and αE Integrins Define a Novel Subset Promoting Intestinal Inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Chronic Inflammation and γδ T Cells.Frontiers in immunology · 2016Review
- Innate mucosal-associated invariant T (MAIT) cells are activated in inflammatory bowel diseases.Clinical and experimental immunology · 2014Article
- Interleukin 23 in Crohn's disease.Inflammatory bowel diseases · 2014Review
- Alteration of DSS-mediated immune cell redistribution in murine colitis by oral colostral immunoglobulin.BMC immunology · 2013Article
- Article
- Skin- and gut-homing molecules on human circulating γδ T cells and their dysregulation in inflammatory bowel disease.Clinical and experimental immunology · 2012Article
- The light and dark sides of intestinal intraepithelial lymphocytes.Nature reviews. Immunology · 2011Review
- Infliximab induces clonal expansion of γδ-T cells in Crohn's disease: a predictor of lymphoma risk?PloS one · 2011Article
- Mechanisms underlying γδ T-cell subset perturbations in SIV-infected Asian rhesus macaques.Blood · 2010Article
- Cytomegalovirus-induced gammadelta T cells associate with reduced cancer risk after kidney transplantation.Journal of the American Society of Nephrology : JASN · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to study the role of gamma/delta T cells in the pathogenesis of inflammatory bowel disease (IBD) in humans, we measured the percentage of these cells in the peripheral blood, assessed the ratio of the non-disulphide-linked (delta TCS1) type of T cell receptor (TCR) in the total gamma/delta T cells, studied the co-expression of gamma/delta TCR and accessory molecules CD8 and CD16, and compared these data with both the type and the activity of the disease. Percentage levels and absolute numbers of gamma/delta+ T cells were higher in active patients than in controls (P < 0.05), mainly as a result of an increase of V delta 1+ (delta TCS1) T cell subset (P < 0.05). This trend was strongly retained independently of disease activity and clinical picture. An increased percentage of TCR delta 1+/CD16+ cells was observed in our patients compared with controls (P < 0.05). In contrast, no difference was observed as far as the TCR delta 1+/CD8+ cells were concerned. These results suggest that IBD is associated with an expansion of gamma/delta T cells in peripheral blood, which may play a role in the pathogenesis of these disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.