ReviewVirchows Archiv : an international journal of pathology1994
Combined sellar gangliocytoma and pituitary adenoma in acromegaly or Cushing's disease. A report of 3 cases.
Review in Virchows Archiv : an international journal of pathology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 80 citations in OpenAlex.
- Endoscopic endonasal surgery using indocyanine green fluorescence endoscope for Cushing's disease caused by mixed intrasellar gangliocytoma and adrenocorticotropin adenoma: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Update on regulation of GHRH and its actions on GH secretion in health and disease.Reviews in endocrine & metabolic disorders · 2025Review
- IgG4-associated hypophysitis coexisting with MALT lymphoma and gangliocytoma: first case report and literature review.Frontiers in neurology · 2023Article
- Multiple tumorous lesions of the pituitary gland.Hormones (Athens, Greece) · 2022Article
- Acromegaly Caused by Ectopic Growth Hormone Releasing Hormone Secretion: A Review.Frontiers in endocrinology · 2022Review
- Observation of Clinicopathologic Features of Pituitary Adenoma With Neuronal Differentiation.Frontiers in endocrinology · 2022Article
- Case report: Clinical and single-cell transcriptome sequencing analysis of a mixed gangliocytoma-adenoma presenting as acromegaly.Frontiers in oncology · 2022Article
- [The 2017 WHO classification of pituitary tumors].Der Pathologe · 2021Article
- Mixed gangliocytoma-pituitary adenoma containing GH and GHRH co-secreting adenoma cells.Endocrinology, diabetes & metabolism case reports · 2019Article
- [Ectopia of the pituitary].Der Pathologe · 2018Review
- Acromegaly associated with gangliocytoma.Irish journal of medical science · 2012Article
- Clinicopathological correlations in pituitary adenomas.Brain pathology (Zurich, Switzerland) · 2012Review
- Review
- Article
- An intrasellar mixed gangliocytoma-adenoma including ependymal component, and review of the literature.BMJ case reports · 2009Article
- Ganglioglioma of the neurohypophysis.Endocrine pathology · 2008Article
- Combined gangliocytoma and prolactinoma of the pituitary gland.Endocrine pathology · 2008Article
- Combined sellar fibrosarcoma and prolactinoma with neuronal metaplasia: report of a case unassociated with radiotherapy.Endocrine pathology · 2004Review
- [Pituitary gland tumors].Der Pathologe · 2003Review
- Prolactin-producing pituitary adenoma and carcinoma with neuronal components--a metaplastic lesion.Pituitary · 1999Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Three cases of a composite sellar tumour composed of a gangliocytoma and an adenoma are presented. Two patients who showed acromegaly and hyperprolactinaemia had a gangliocytoma and a growth hormone (GH)-prolactin cell adenoma in close proximity. The gangliocytoma contained growth hormone-releasing hormone (GHRH) by immunohistochemistry. At the electron microscopical level, the gangliocytoma was characterized by numerous synaptic vesicles. The third patient, a child with Cushing's disease, presented a corticotropin-releasing hormone (CRH)-positive gangliocytoma in close contact with an adrenocorticotropic hormone (ACTH) secreting adenoma, the latter a typical densely granulated ACTH cell adenoma. Ultrastructurally, the gangliocytoma revealed synaptic vesicles and sparse secretory granules. The results suggest that gangliocytomas may promote the development of pituitary adenomas by hypersecretion of releasing hormones. Whereas 20 cases of sellar GHRH producing gangliocytomas in acromegaly are reported in the literature, the combination of a CRH-positive gangliocytoma and an ACTH cell adenoma in Cushing's disease is apparently the first case.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.