ArticleBiophysical journal1994
Calcium signaling in restricted diffusion spaces.
Article in Biophysical journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Article
- A computational model predicts sex-specific responses to calcium channel blockers in mammalian mesenteric vascular smooth muscle.bioRxiv : the preprint server for biology · 2024Article
- Mechanisms of Vascular Smooth Muscle Contraction and the Basis for Pharmacologic Treatment of Smooth Muscle Disorders.Pharmacological reviews · 2016Review
- Regulation of cellular communication by signaling microdomains in the blood vessel wall.Pharmacological reviews · 2014Review
- Phospholamban phosphorylation increases the passive calcium leak from cardiac sarcoplasmic reticulum.Pflugers Archiv : European journal of physiology · 2012Article
- Modulation of T cell activation by localized K⁺ accumulation at the immunological synapse--a mathematical model.Journal of theoretical biology · 2012Article
- A 3D Monte Carlo analysis of the role of dyadic space geometry in spark generation.Biophysical journal · 2006Article
- Ca2+ regulation in the near-membrane microenvironment in smooth muscle cells.Biophysical journal · 2003Article
- Ca(2+) regulation in guinea-pig colonic smooth muscle: the role of the Na(+)-Ca(2+) exchanger and the sarcoplasmic reticulum.The Journal of physiology · 2002Article
- Ca2+-dependent and Ca2+-independent regulation of smooth muscle contraction.Journal of muscle research and cell motility · 2002Review
- Underlying mechanisms of symmetric calcium wave propagation in rat ventricular myocytes.Biophysical journal · 2001Article
- Numerical simulation of Ca2+ "sparks" in skeletal muscle.Biophysical journal · 1999Article
- Mathematical modeling and fluorescence imaging to study the Ca2+ turnover in skinned muscle fibers.Biophysical journal · 1998Article
- Assessment of frequency-dependent alterations in the level of extracellular Ca2+ in the synaptic cleft.Biophysical journal · 1997Article
- Modulation of L-type Ca2+ current by fast and slow Ca2+ buffering in guinea pig ventricular cardiomyocytes.Biophysical journal · 1997Article
- The temporal profile of calcium transients in voltage clamped gastric myocytes from Bufo marinus.The Journal of physiology · 1996Article
- Near-membrane [Ca2+] transients resolved using the Ca2+ indicator FFP18.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Calcium concentration and movement in the diadic cleft space of the cardiac ventricular cell.Biophysical journal · 1996Article
- Cytochemical localization of Ca(2+)-ATPases and demonstration of ATP-dependent calcium sequestration in giant smooth muscle fibres of Beroe.Journal of muscle research and cell motility · 1996Article
- Dissociation of subsarcolemmal from global cytosolic [Ca2+] in myocytes from guinea-pig coronary artery.The Journal of physiology · 1996Article
Corrections and comments
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1 author.
Funding
Abstract
One- and two-dimensional models of Ca2+ diffusion and regulation were developed and used to study the magnitudes and the spatial and temporal characteristics of the Ca2+ transients that are likely to develop in smooth muscle cells in restricted diffusion spaces between the plasma membrane and intracellular organelles. Simulations with the models showed that high [Ca2+] (on the order of several microM) can develop in such spaces and persist for 100-200 ms. These Ca2+ transients could: 1) facilitate the coupling of Ca2+ influx to intracellular Ca2+ release; 2) provide a mechanism for the regulation of stored Ca2+ that does not affect the contractile state of smooth muscle; 3) locally activate specific signal transduction pathways, before, or without activating other Ca2+ dependent pathways in the central cytoplasm of the cell. The latter possibility suggests that independent enzymatic processes in cells could be differentially regulated by the same intracellular second messenger.
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