ArticleBiophysical journal1994
Fast single-channel measurements resolve the blocking effect of Cs+ on the K+ channel.
Article in Biophysical journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- How to resolve microsecond current fluctuations in single ion channels: the power of beta distributions.Channels (Austin, Tex.) · 2015Review
- Ca2+ block and flickering both contribute to the negative slope of the IV curve in BK channels.The Journal of general physiology · 2013Article
- Modulation of enrofloxacin binding in OmpF by Mg2+ as revealed by the analysis of fast flickering single-porin current.The Journal of general physiology · 2012Article
- Using a five-state model for fitting amplitude histograms from MaxiK channels: beta-distributions reveal more than expected.European biophysics journal : EBJ · 2009Article
- Fast and slow gating are inherent properties of the pore module of the K+ channel Kcv.The Journal of general physiology · 2009Article
- Four-mode gating model of fast inactivation of sodium channel Nav1.2a.Pflugers Archiv : European journal of physiology · 2008Article
- Tl+-induced micros gating of current indicates instability of the MaxiK selectivity filter as caused by ion/pore interaction.The Journal of general physiology · 2008Article
- Saturation and microsecond gating of current indicate depletion-induced instability of the MaxiK selectivity filter.The Journal of general physiology · 2007Article
- Strengths and limits of Beta distributions as a means of reconstructing the true single-channel current in patch clamp time series with fast gating.The Journal of membrane biology · 2006Article
- Distributions-per-level: a means of testing level detectors and models of patch-clamp data.The Journal of membrane biology · 2004Article
- The anomalous mole fraction effect in Chara: gating at the edge of temporal resolution.Biophysical journal · 2000Article
- Patch clamp study of the voltage-dependent anion channel in the thylakoid membrane.The Journal of membrane biology · 1995Article
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Authors and funding
2 authors.
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Abstract
The Cs+ block of K+ channels has often been investigated by methods that allow only indirect estimation of the rate constants of blocking and re-opening. This paper presents single-channel records with high temporal resolution which make the direct observation of the fast transitions between the blocked and the unblocked state possible. The rate constants kOGb, kGbO of Cs(+)-dependent blocking and of re-opening are evaluated from the time constants found in the open-time and closed-time histograms. The blocking rate constant kOGb between 1000 and 50000 s-1 depends linearly on the Cs+ concentration and strongly on voltage, increasing by a factor of 1.44 per 10 mV hyperpolarization. The re-opening rate constant kGbO approximately 30000 s-1 is independent of Cs+ concentration and only slightly voltage-dependent. Formally, the results can be described by a Woodhull-model. The strong voltage dependence with d > 1, however, weakens its plausibility. The results are interpreted in terms of a molecular framework emerging from recent results on the structure of voltage-gated channels.
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