ArticlePediatric nephrology (Berlin, Germany)1994
Glomerular volume and renal function in children with different types of the nephrotic syndrome.
Article in Pediatric nephrology (Berlin, Germany), 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 23 citations in OpenAlex.
- Role of glomerular filtration rate-modifying drugs in the development of anticoagulant-related nephropathy.Physiological reports · 2021Article
- EndothelialJournal of the American Society of Nephrology : JASN · 2017Article
- Minimal change disease and idiopathic FSGS: manifestations of the same disease.Nature reviews. Nephrology · 2016Review
- Podocyte Number in Children and Adults: Associations with Glomerular Size and Numbers of Other Glomerular Resident Cells.Journal of the American Society of Nephrology : JASN · 2015Article
- Sickle cell disease and the kidney.Nature clinical practice. Nephrology · 2009Review
- Follow-up of kidney biopsies in normoalbuminuric patients with type 1 diabetes.Pediatric nephrology (Berlin, Germany) · 2004Article
- Glomerular structural factors in progression of congenital nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2003Article
- Focal segmental glomerulosclerosis.Pediatric nephrology (Berlin, Germany) · 1996Review
- Quantitative analysis of glomeruli lesions in patients with mesangial proliferative glomerulonephritis.Journal of Tongji Medical University = Tong ji yi ke da xue xue bao · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glomerular hypertrophy has been suggested to be an important factor in the pathogenesis of focal glomerular sclerosis. The aim of the present study was to analyse retrospectively the renal biopsies of 58 children (0.2-16.1 years of age) with different types of the nephrotic syndrome, minimal change nephrotic syndrome (MCNS), diffuse mesangial proliferation (DMP) and focal segmental glomerulosclerosis (FSGS). Glomerular surface area was measured and glomerular volume was calculated and related to steroid responsiveness and to renal function, measured by clearances of inulin and para-aminohippuric acid. Glomerular volume correlated with body surface area (BSA) and age. Because of this, patients with FSGS and DMP were matched according to BSA and age, with corresponding MCNS patients. Glomerular volumes of FSGS and DMP patients were significantly larger than those of MCNS patients. In the MCNS patients, significant correlations were found between glomerular volumes and glomerular filtration rate and effective renal plasma flow. Steroid-dependent and steroid-resistant patients showed larger glomeruli than the steroid-responsive children. We suggest that hyperfiltration and hyperperfusion, among other factors, may contribute to glomerular hypertrophy, mesangial proliferation and glomerulosclerosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.