ArticleGenetics1994
Molecular genetics of the brown (b)-locus region of mouse chromosome 4. I. Origin and molecular mapping of radiation- and chemical-induced lethal brown deletions.
Article in Genetics, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 24 citations in OpenAlex.
- Genomic anatomy of the Tyrp1 (brown) deletion complex.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- X-ray-induced deletion complexes in embryonic stem cells on mouse chromosome 15.Mammalian genome : official journal of the International Mammalian Genome Society · 2005Article
- The Tyr (albino) locus of the laboratory mouse.Mammalian genome : official journal of the International Mammalian Genome Society · 2004Article
- The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Interdigitated deletion complexes on mouse chromosome 5 induced by irradiation of embryonic stem cells.Genome research · 2000Article
- Deletion mapping of the head tilt (het) gene in mice: a vestibular mutation causing specific absence of otoliths.Genetics · 1998Article
- Differential response of mouse male germ-cell stages to radiation-induced specific-locus and dominant mutations.Genetics · 1998Article
- Complementation analyses for 45 mutations encompassing the pink-eyed dilution (p) locus of the mouse.Genetics · 1995Article
- A high-resolution map of the brown (b, Tyrp1) deletion complex of mouse chromosome 4.Mammalian genome : official journal of the International Mammalian Genome Society · 1995Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over a period of many years, germ-cell mutagenesis experiments using the mouse specific-locus test have generated numerous radiation- and chemical-induced alleles of the brown (b; Tyrp 1) locus in mouse chromosome 4. We describe here the origin, maintenance and initial molecular characterization of 28 b mutations that are prenatally lethal when homozygous. Each of these mutations is deleted for Tyrp 1 sequences, and each of 25 mutations tested further is deleted for at least one other locus defined by molecular clones previously found to be closely linked to b by interspecific backcross analysis. A panel of DNAs from mice carrying a lethal b mutation and a Mus spretus chromosome 4 was used in the fine structure mapping of these molecularly defined loci. The deletional nature of each of these prenatally lethal mutations is consistent with the hypothesis that the null phenotype at b has an effect only on the quality (color) of eumelanin produced in melanocytes. The resulting deletion map provides a framework on which to build future molecular-genetic and biological analyses of this region of mouse chromosome 4.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.