ArticleImmunogenetics1994
Recombination in the class III region of the mouse major histocompatibility complex.
Article in Immunogenetics, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 16 citations in OpenAlex.
- High-resolution patterns of meiotic recombination across the human major histocompatibility complex.American journal of human genetics · 2002Article
- Meiotic recombination hotspots: shaping the genome and insights into hypervariable minisatellite DNA change.Current topics in developmental biology · 1998Review
- Recombination hotspot activity of hypervariable minisatellite DNA requires minisatellite DNA binding proteins.Somatic cell and molecular genetics · 1998Article
- Characterization of recombination in the HLA class II region.American journal of human genetics · 1997Article
- Meiotic recombination at the Lmp2 hotspot tolerates minor sequence divergence between homologous chromosomes.Immunogenetics · 1996Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The sites of meiotic recombination in the class II region of the mouse major histocompatibility complex (MHC) are clustered at hotspots. To search for hotspots in the class III region, we mapped recombinational breakpoints of 79 Ab:H2-D recombinants with 11 DNA markers; these included Tnx, the gene for an extracellular matrix protein, tenascin X, the Notch-related Int3 gene, and a microsatellite marker, D17Mit13, none of which had previously been mapped precisely. The results gave the gene order of Eb-61.1-Int3-Tnx-Cyp21/C4-Bf-Hsp68c-D17Mit13+ ++-Tnfa/Tnfb-D. The crossover sites in 40 of the 79 recombinants were confined within the Eb/Int3:Tnx/Cyp21 interval. The result demonstrated that an unequal distribution of recombination is a general feature of the mouse MHC, suggesting the presence of a recombinational hotspot within the Int3:Tnx interval.
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Registered trials
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