ArticleProceedings of the National Academy of Sciences of the United States of America1994
Structure of homeobox-leucine zipper genes suggests a model for the evolution of gene families.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 79 citations in OpenAlex.
- SIZ1-mediated SUMOylation of HAT1 enhances plant thermotolerance in Arabidopsis.The Plant journal : for cell and molecular biology · 2026Article
- Genome-wide association studies for earliness, MYMIV resistance, and other associated traits in mungbean (PeerJ · 2024Article
- The START domain mediates Arabidopsis GLABRA2 dimerization and turnover independently of homeodomain DNA binding.Plant physiology · 2022Article
- Arabidopsis homeobox-leucine zipper transcription factor BRASSINOSTEROID-RELATED HOMEOBOX 3 regulates leaf greenness by suppressing BR signaling.Plant biotechnology (Tokyo, Japan) · 2022Article
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- Integrated microRNA and mRNA expression profiling reveals a complex network regulating pomegranate (Punica granatum L.) seed hardness.Scientific reports · 2018Article
- Overexpression of the class I homeodomain transcription factor TaHDZipI-5 increases drought and frost tolerance in transgenic wheat.Plant biotechnology journal · 2018Article
- Transcription factor HAT1 is a substrate of SnRK2.3 kinase and negatively regulates ABA synthesis and signaling in Arabidopsis responding to drought.PLoS genetics · 2018Article
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- Genome-wide identification and expression analyses of the homeobox transcription factor family during ovule development in seedless and seeded grapes.Scientific reports · 2017Article
- Transcription Factors in Fungi: TFome Dynamics, Three Major Families, and Dual-Specificity TFs.Frontiers in genetics · 2017Article
- Molecular evolution and gene expression differences within the HD-Zip transcription factor family of Zea mays L.Genetica · 2016Article
- ATHB17 is a positive regulator of abscisic acid response during early seedling growth.Molecules and cells · 2013Article
- The Arabidopsis thaliana homeobox gene ATHB12 is involved in symptom development caused by geminivirus infection.PloS one · 2011Article
- A genome-wide survey of HD-Zip genes in rice and analysis of drought-responsive family members.Plant molecular biology · 2008Article
- A homeodomain leucine zipper gene from Craterostigma plantagineum regulates abscisic acid responsive gene expression and physiological responses.Plant molecular biology · 2006Article
- Homeodomain leucine zipper class I genes in Arabidopsis. Expression patterns and phylogenetic relationships.Plant physiology · 2005Article
- START lipid/sterol-binding domains are amplified in plants and are predominantly associated with homeodomain transcription factors.Genome biology · 2004Article
- Homez, a homeobox leucine zipper gene specific to the vertebrate lineage.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Homeobox genes are present in both plants and animals. Homeobox-leucine zipper genes, however, have been identified thus far only in the small mustard plant Arabidopsis thaliana. This observation suggests that homeobox-leucine zipper genes evolved after the divergence of plants and animals, perhaps to mediate specific regulatory events. To better understand this gene family, we isolated several sequences containing the homeobox-leucine zipper motif and carried out a comparative analysis of nine homeobox-leucine zipper genes (HAT1, HAT2, HAT3, HAT4, HAT5, HAT7, HAT9, HAT14, and HAT22). Gene structures, sequence comparisons, and chromosomal locations suggest a simple model for the evolution of these genes. The model postulates that a primordial homeobox gene acquired a leucine zipper by exon capture. The nascent homeobox-leucine zipper gene then appears to have undergone a series of gene duplication and chromosomal translocation events, leading to the formation of the HAT gene family. This work has general implications for the evolution of regulatory genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.