ArticleThe EMBO journal1994
The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins.
Article in The EMBO journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
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Who cites it
86 citing papers in PubMed.
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- CDX2 dose-dependently influences the gene regulatory network underlying human extraembryonic mesoderm development.Biology open · 2024Article
- CDX2 dose-dependently influences the gene regulatory network underlying human extraembryonic mesoderm development.bioRxiv : the preprint server for biology · 2024Article
- Zinc finger myeloid Nervy DEAF-1 type (ZMYND) domain containing proteins exert molecular interactions to implicate in carcinogenesis.Discover oncology · 2022Review
- Characterizing Hox genes in mayflies (Ephemeroptera), with Hexagenia limbata as a new mayfly model.EvoDevo · 2022Article
- Transcription factor paralogs orchestrate alternative gene regulatory networks by context-dependent cooperation with multiple cofactors.Nature communications · 2022Article
- Single-cell RNA sequencing of motoneurons identifies regulators of synaptic wiring in Drosophila embryos.Molecular systems biology · 2022Article
- The Hox protein conundrum: The "specifics" of DNA binding for Hox proteins and their partners.Developmental biology · 2021Review
- Hedgehog/GLI Signaling Pathway: Transduction, Regulation, and Implications for Disease.Cancers · 2021Review
- Dynamic Molecular Evolution of Mammalian Homeobox Genes: Duplication, Loss, Divergence and Gene Conversion Sculpt PRD Class Repertoires.Journal of molecular evolution · 2021Article
- Anterior Hox Genes and the Process of Cephalization.Frontiers in cell and developmental biology · 2021Review
- Differential abilities to engage inaccessible chromatin diversify vertebrate Hox binding patterns.Development (Cambridge, England) · 2020Article
- In vivo Hox binding specificity revealed by systematic changes to a single cis regulatory module.Nature communications · 2019Article
- Regulation of Silk Genes by Hox and Homeodomain Proteins in the Terminal Differentiated Silk Gland of the Silkworm Bombyx mori.Journal of developmental biology · 2016Review
- Co-option of an Ancestral Hox-Regulated Network Underlies a Recently Evolved Morphological Novelty.Developmental cell · 2015Article
- Transvection-based gene regulation in Drosophila is a complex and plastic trait.G3 (Bethesda, Md.) · 2014Article
- Phosphorylation of Shox2 is required for its function to control sinoatrial node formation.Journal of the American Heart Association · 2014Article
- Sequence-specific interaction between ABD-B homeodomain and castor gene in Drosophila.BMB reports · 2014Article
26 more citing papers are in PubMed but not listed here.
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6 authors.
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Abstract
The homeodomain has been implicated as a major determinant of biological specificity for the homeotic selector (HOM) genes. We compare here the DNA sequence preferences of homeodomains encoded by four of the eight Drosophila HOM proteins. One of the four, Abdominal-B, binds preferentially to a sequence with an unusual 5'-T-T-A-T-3' core, whereas the other three prefer 5'-T-A-A-T-3'. Of these latter three, the Ultrabithorax and Antennapedia homeodomains display indistinguishable preferences outside the core while Deformed differs. Thus, with three distinct binding classes defined by four HOM proteins, differences in individual site recognition may account for some but not all of HOM protein functional specificity. We further show that amino acid residues within the N-terminal arm are responsible for the sequence specificity differences between the Ultrabithorax and Abdominal-B homeodomains. Similarities and differences at the corresponding positions within the N-terminal arms are conserved in the vertebrate Abdominal-B-like HOM proteins, which play critical roles in limb specifications as well as in regional specification along the anterior-posterior axis. This and other patterns of residue conservation suggest that differential DNA sequence recognition may play a role in HOM protein function in a wide range of organisms.
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