ArticleProceedings of the National Academy of Sciences of the United States of America1994
Leukemia inhibitory factor induces neurotransmitter switching in transgenic mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 72 citations in OpenAlex.
- The role of the TGF-β/LIF signaling pathway mediated by SMADs during the cyst formation of Echinococcus in young children.BMC molecular and cell biology · 2022Article
- The sympathetic nervous system in development and disease.Nature reviews. Neuroscience · 2021Review
- The unique expression profile of FAM19A1 in the mouse brain and its association with hyperactivity, long-term memory and fear acquisition.Scientific reports · 2020Article
- Expression of Tyrosine Hydroxylase is Negatively Regulated Via Prion Protein.Neurochemical research · 2016Article
- Neurotransmitter Switching? No Surprise.Neuron · 2015Review
- Heart failure causes cholinergic transdifferentiation of cardiac sympathetic nerves via gp130-signaling cytokines in rodents.The Journal of clinical investigation · 2010Article
- Neurotrophic actions of PACAP-38 and LIF on human neuroblastoma SH-SY5Y cells.Journal of molecular neuroscience : MN · 2008Article
- Activity-dependent neuron-glial signaling by ATP and leukemia-inhibitory factor promotes hippocampal glial cell development.Neuron glia biology · 2008Article
- Expression and function of leukaemia inhibitory factor and its receptor in normal and regenerating rat pancreas.Diabetologia · 2006Article
- Transgenic models of pancreatic cancer.International journal of gastrointestinal cancer · 2003Review
- Developmental regulation of neurotransmitter phenotype through tetrahydrobiopterin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Leukemia inhibitory factor inhibits neuronal terminal differentiation through STAT3 activation.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Nerve growth factor antiserum induces axotomy-like changes in neuropeptide expression in intact sympathetic and sensory neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- The cholinergic neuronal phenotype in Alzheimer's disease.Metabolic brain disease · 2000Review
- Leukemia inhibitory factor induces sympathetic sprouting in intact dorsal root ganglia in the adult rat in vivo.The Journal of physiology · 1998Article
- Pituitary-directed leukemia inhibitory factor transgene forms Rathke's cleft cysts and impairs adult pituitary function. A model for human pituitary Rathke's cysts.The Journal of clinical investigation · 1997Article
- The expression pattern of the transcription factor Phox2 delineates synaptic pathways of the autonomic nervous system.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1996Article
- Influence of leukemia inhibitory factor on galanin/GMAP and neuropeptide Y expression in mouse primary sensory neurons after axotomy.Experimental brain research · 1996Article
- Leukemia inhibitory factor induces differentiation of pituitary corticotroph function: an immuno-neuroendocrine phenotypic switch.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Expression of peptides, nitric oxide synthase and NPY receptor in trigeminal and nodose ganglia after nerve lesions.Experimental brain research · 1996Article
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5 authors at 1 institution in 1 country.
Funding
Abstract
Leukemia inhibitory factor (LIF) is a cytokine growth factor that induces rat sympathetic neurons to switch their neurotransmitter phenotype from noradrenergic to cholinergic in vitro. To test whether LIF can influence neuronal differentiation in vivo, we generated transgenic mice that expressed LIF in pancreatic islets under the control of the insulin promoter and evaluated the neurotransmitter phenotype of the pancreatic sympathetic innervation. We also used the insulin promoter to coexpress nerve growth factor in the islets, which greatly increased the density of sympathetic innervation and facilitated analysis of the effects of LIF. Our data demonstrate that tyrosine hydroxylase and catecholamines declined and choline acetyltransferase increased in response to LIF. We conclude that LIF can induce neurotransmitter switching of sympathetic neurons in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.