ArticleThe Journal of experimental medicine1994
Major histocompatibility complex class II expression distinguishes two distinct B cell developmental pathways during ontogeny.
Article in The Journal of experimental medicine, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 50 citations in OpenAlex.
- Single-cell genomics identifies distinct B1 cell developmental pathways and reveals aging-related changes in the B-cell receptor repertoire.Cell & bioscience · 2022Article
- Crucial Role of Increased Arid3a at the Pre-B and Immature B Cell Stages for B1a Cell Generation.Frontiers in immunology · 2019Article
- Fetal Lymphoid Progenitors Become Restricted to B-1 Fates Coincident with IL-7Rα Expression.PloS one · 2016Article
- Reduced production of B-1-specified common lymphoid progenitors results in diminished potential of adult marrow to generate B-1 cells.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Genetic control of the B cell response to LPS: opposing effects in peritoneal versus splenic B cell populations.Immunogenetics · 2010Article
- Phenotypically distinct B cell development pathways map to the three B cell lineages in the mouse.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Delayed cellular maturation and decreased immunoglobulin kappa light chain production in immature B lymphocytes lacking B cell linker protein.The Journal of experimental medicine · 2002Article
- Regulated expression of human histocompatibility leukocyte antigen (HLA)-DO during antigen-dependent and antigen-independent phases of B cell development.The Journal of experimental medicine · 2002Article
- Identification of a germ-line pro-B cell subset that distinguishes the fetal/neonatal from the adult B cell development pathway.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- B cell antigen receptor specificity and surface density together determine B-1 versus B-2 cell development.The Journal of experimental medicine · 1999Article
- c-Myb is essential for early T cell development.Genes & development · 1999Article
- Rapid elimination of mature autoreactive B cells demonstrated by Cre-induced change in B cell antigen receptor specificity in vivo.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation.Nature genetics · 1997Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
All mature B cells coexpress major histocompatibility complex (MHC) class II molecules, I-A and I-E, which are restriction elements required for antigen presentation to CD4+ T cells. However, the expression of class II during the early stages of B cell development has been unclear. We demonstrate here that there is a difference in the expression of class II during murine B cell development in the fetal liver and adult bone marrow (BM). These differences define two distinct B cell developmental pathways. The Fetal-type (FT) pathway is characterized by pre-B and immature IgM+ B cells generated in the fetal liver which initially lack all class II expression. In contrast, the Adult-type (AT) pathway is typified by B cells developing in the adult BM which express class II molecules from the pre-B cell stage. In vitro stromal cell cultures of sorted fetal liver and adult BM pro-B cells indicated that the difference in I-A expression during B cell development is intrinsic to the progenitors. In addition, we show that FT B cell development is not restricted to the fetal liver but occurs in the peritoneal cavities, spleens, liver, and BM of young mice up to at least 1 mo of age. The AT B cell development begins to emerge after birth but is, however, restricted to the BM environment. These findings indicate that there are two distinct B cell developmental pathways during ontogeny, each of which could contribute differentially to the immune repertoire and thus the functions of B cell subsets and lineages.
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