ArticleThe EMBO journal1994
The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins.
Article in The EMBO journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- Unraveling the Complex Interplay Between Transcription Factors and Signaling Molecules in Thyroid Differentiation and Function, From Embryos to Adults.Frontiers in endocrinology · 2021Review
- Lung Regeneration: Endogenous and Exogenous Stem Cell Mediated Therapeutic Approaches.International journal of molecular sciences · 2016Review
- Gene regulatory networks governing lung specification.Journal of cellular biochemistry · 2014Review
- ErbB4 is an upstream regulator of TTF-1 fetal mouse lung type II cell development in vitro.Biochimica et biophysica acta · 2013Article
- Thyroid transcription factor-1 (TTF-1) gene: identification of ZBP-89, Sp1, and TTF-1 sites in the promoter and regulation by TNF-α in lung epithelial cells.American journal of physiology. Lung cellular and molecular physiology · 2011Article
- In vivo role of different domains and of phosphorylation in the transcription factor Nkx2-1.BMC developmental biology · 2011Article
- Hox specificity unique roles for cofactors and collaborators.Current topics in developmental biology · 2009Review
- TTF-1 response element is critical for temporal and spatial regulation and necessary for hormonal regulation of human surfactant protein-A2 promoter activity.American journal of physiology. Lung cellular and molecular physiology · 2008Article
- Expression of homeotic genes Hoxa3, Hoxb3, Hoxd3 and Hoxc4 is decreased in the lungs but not in the hearts of adriamycin-exposed mice.Pediatric surgery international · 2007Article
- Origin of the ultimobranchial body cyst: T/ebp/Nkx2.1 expression is required for development and fusion of the ultimobranchial body to the thyroid.Developmental dynamics : an official publication of the American Association of Anatomists · 2006Article
- Article
- BP1, a homeodomain-containing isoform of DLX4, represses the beta-globin gene.Molecular and cellular biology · 2002Article
- Homeobox B3 promotes capillary morphogenesis and angiogenesis.The Journal of cell biology · 2000Article
- Definition of the transcriptional activation domains of three human HOX proteins depends on the DNA-binding context.Molecular and cellular biology · 1998Article
- Functional dissection of a transcriptionally active, target-specific Hox-Pbx complex.The EMBO journal · 1997Article
- Oct-1 interacts with conserved motifs in the human thyroid transcription factor 1 gene minimal promoter.The Biochemical journal · 1996Article
- Hox genes in the lung.American journal of respiratory cell and molecular biology · 1996Review
- Hepatocyte nuclear factor 3 activates transcription of thyroid transcription factor 1 in respiratory epithelial cells.Molecular and cellular biology · 1996Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vertebrate Hox homeobox genes are transcription factors which regulate antero-posterior axial identity in embryogenesis, presumably through activation and/or repression of downstream target genes. Some of these targets were reported to code for molecules involved in cell-cell interactions, whereas no relationship has yet been demonstrated between Hox genes and other transcription factors involved in determining and/or maintaining tissue specificity. The thyroid transcription factor-1 (TTF-1) is a homeodomain-containing protein required for expression of thyroid-specific genes. A 862 bp 5' genomic fragment of the rat TTF-1 gene, conferring thyroid-specific expression to a reporter gene, was sufficient to mediate transactivation by the human HOXB3 gene in co-transfection assay in both NIH3T3 or HeLa cells. HOXB3 is expressed in early mammalian embryogenesis in the anterior neuroectoderm, branchial arches and their derivatives, including the area of the thyroid primordia and thyroid gland. Transcription of the TTF-1 promoter is induced only by HOXB3, while its paralogous gene HOXD3 or other Hox genes expressed more posteriorly (HOXA4, HOXD4, HOXC5, HOXC6, HOXC8 and Hoxd-8) have no effect. Transactivation by HOXB3 is mediated by two binding sites containing an ATTA core located at -100 and +30 from the transcription start site. DNase I footprinting experiments show that the two sites bind HOXB3 protein synthesized in both Escherichia coli and eukaryotic cells, as well as nuclear factor(s) present in protein extracts obtained from mouse embryonic tissues which express group 3 Hox genes and TTF-1. Some of the DNA-protein complexes formed by the embryonic extracts are indistinguishable from those generated by HOXB3.(ABSTRACT TRUNCATED AT 250 WORDS)
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