ArticleThe American journal of pathology1994
Keratinocyte growth factor induces pancreatic ductal epithelial proliferation.
Article in The American journal of pathology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 85 citations in OpenAlex.
- Purified human pancreatic duct cell culture conditions defined by serum-free high-content growth factor screening.PloS one · 2012Trial
- Fibroblast growth factor 7 releasing particles enhance islet engraftment and improve metabolic control following islet transplantation in mice with diabetes.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021Article
- Enhanced FGFR signalling predisposes pancreatic cancer to the effect of a potent FGFR inhibitor in preclinical models.British journal of cancer · 2014Article
- Article
- Mechanisms of KGF mediated signaling in pancreatic duct cell proliferation and differentiation.PloS one · 2009Article
- Treatment of streptozotocin-induced diabetes mellitus in mice by intra-bone marrow bone marrow transplantation plus portal vein injection of beta cells induced from bone marrow cells.International journal of hematology · 2007Article
- Enhanced expression of keratinocyte growth factor and its receptor correlates with venous invasion in pancreatic cancer.The American journal of pathology · 2007Article
- Development of the endocrine pancreas.Reviews in endocrine & metabolic disorders · 2005Review
- Pancreatic stem cells: differentiation options.Stem cell reviews · 2005Review
- Keratinocyte growth factor and beta-cell differentiation in human fetal pancreatic endocrine precursor cells.Diabetologia · 2003Article
- Angiogenesis and antiangiogenic strategies in pancreatic cancer.International journal of gastrointestinal cancer · 2003Review
- The effects of keratinocyte growth factor in preclinical models of mucositis.Cell proliferation · 2002Review
- Cell kinetic studies in the murine ventral tongue epithelium: the effects of repeated exposure to keratinocyte growth factor.Cell proliferation · 2002Article
- In vitro cultivation of human islets from expanded ductal tissue.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Regulation of keratinocyte growth factor (KGF) and KGF receptor mRNAs by nutrient intake and KGF administration in rat intestine.Digestive diseases and sciences · 2000Article
- Pancreatic expression of keratinocyte growth factor leads to differentiation of islet hepatocytes and proliferation of duct cells.The American journal of pathology · 1999Article
- Characterization of keratinocyte growth factor and receptor expression in human pancreatic cancer.The American journal of pathology · 1998Article
- Pulmonary malformation in transgenic mice expressing human keratinocyte growth factor in the lung.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Intratracheal instillation of keratinocyte growth factor decreases hyperoxia-induced mortality in rats.The Journal of clinical investigation · 1995Article
- Keratinocyte growth factor: an androgen-regulated mediator of stromal-epithelial interactions in the prostate.World journal of urology · 1995Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Keratinocyte growth factor (KGF) causes a proliferation of pancreatic ductal epithelial cells in adult rats after daily systemic administration for 1 to 2 weeks. Even before the proliferation of intralobular ducts is histologically evident, KGF also induces proliferating cell nuclear antigen expression within the ductal epithelium of intercalated, intralobular, and interlobular ducts. KGF also causes incorporation of 5-bromodeoxyuridine in ductal epithelial cells. Epithelial cell proliferation is histologically most prominent at the level of the intralobular ducts adjacent to and within the islets of Langerhans. Pancreatic ductal proliferation is not histologically apparent in rats sacrificed 7 to 10 days after the cessation of KGF administration. The pancreatic hormones insulin, glucagon, somatostatin, and pancreatic polypeptide are normally distributed within islets that demonstrate intrainsular ductal proliferation. The proliferating ductal epithelium does not show endocrine differentiation as evidenced by the lack of immunoreactivity for pancreatic hormones. KGF is a potent in vivo mitogen for pancreatic ductal epithelial cells.
Indexed as
Identifiers
7913296PMC1887296W114770942What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.