Genetic variation at the ApoB 3'HVR, D2S44, and D7S21 loci in the Ewondo Ethnic Group of Cameroon.

G Destro-Bisol, S Presciuttini, E d'Aloja, M Dobosz, G Spedini, V L Pascali

Abstract readComparative Study

In one paragraph

Article in American journal of human genetics, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

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3 · Its place in the literature

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1 citing paper in PubMed.

Short tandem-repeat polymorphism/alu haplotype variation at the PLAT locus: implications for modern human origins.American journal of human genetics · 2000
Article

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5 · Who and what money

Authors and funding

6 authors.

G Destro-BisolLaboratorio di Immunoematologia, Università Cattolica del S. Cuore, Rome, Italy.

S Presciuttini

E d'Aloja

M Dobosz

G Spedini

V L Pascali

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A sample of the Ewondo population (a Bantu-speaking group of Southern Cameroon) was analyzed for the polymorphism at three tandem repeated DNA loci (ApoB 3' HVR, D2S44, and D7S21). We observed a greater number of ApoB 3' HVR alleles (17) and a significantly higher estimated heterozygosity (.879 +/- .011) than in previously surveyed populations, with the exception of U.S. Blacks. The higher genetic variability of Ewondo and U.S. Blacks was also shown by the ApoB 3' HVR allele-frequency spectra. A method for measuring population distances, based on cumulative fragment-size distribution, is described. Interpopulation comparisons for ApoB 3' HVR were carried out by this method and were compared with those obtained by a genetic distance measurement. The two sets of results showed a consistent pattern of population differentiation: the Ewondos and the U.S. Blacks clustered together and were well apart from both a Caucasian cluster (Swedes, U.S. Whites, Italians, and Germans) and other well-defined populations (Sikhs of India and Pehuence Indians of Chile). Profile distances were then computed from D2S44 and D7S21 bined data. This analysis indicated a genetic affinity between Ewondos, U.S. Blacks, and Afro-Caribbean Blacks and outlined the genetic diversity between Ewondos, Caucasians, and Asian Indians.

Indexed as

Genetic VariationModels, GeneticPhylogenyAfrica South of the SaharaAllelesApolipoproteins BBlack or African AmericanBlack PeopleCameroonCaribbean RegionChromosomes, Human, Pair 2Chromosomes, Human, Pair 7Gene FrequencyHumansIndiaIndians, South AmericanApolipoproteins B

Identifiers

PMID7912886

PMCPMC1918238

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