ArticleProceedings of the National Academy of Sciences of the United States of America1994
Structure and polymorphism of the mouse prion protein gene.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 104 citations in OpenAlex.
- The Evolution of Experimental Rodent Models for Prion Diseases.Journal of neurochemistry · 2025Review
- Modulation of prion protein expression through cryptic splice site manipulation.bioRxiv : the preprint server for biology · 2023Article
- Factors other than hTau overexpression that contribute to tauopathy-like phenotype in rTg4510 mice.Nature communications · 2019Article
- Implications of peptide assemblies in amyloid diseases.Chemical Society reviews · 2017Review
- The biological function of the cellular prion protein: an update.BMC biology · 2017Review
- CpG site DNA methylation patterns reveal a novel regulatory element in the mouse prion protein gene.The Journal of veterinary medical science · 2017Article
- Endoplasmic reticulum stress induces PRNP prion protein gene expression in breast cancer.Breast cancer research : BCR · 2013Article
- Differential responses of neuronal and spermatogenic cells to the doppel cytotoxicity.PloS one · 2013Article
- Mutability of prions.EMBO reports · 2011Article
- Prion protein expression and functional importance in skeletal muscle.Antioxidants & redox signaling · 2011Article
- The extracellular regulated kinase-1 (ERK1) controls regulated alpha-secretase-mediated processing, promoter transactivation, and mRNA levels of the cellular prion protein.The Journal of biological chemistry · 2011Article
- Prion strain discrimination based on rapid in vivo amplification and analysis by the cell panel assay.PloS one · 2009Article
- A national survey on the allelic, genotypic, and haplotypic distribution of PRNP insertion and deletion polymorphisms in Korean cattle.Journal of genetics · 2009Article
- Identification of adjacent binding sites for the YY1 and E4BP4 transcription factors in the ovine PrP (Prion) gene promoter.The Journal of biological chemistry · 2009Article
- Prion protein gene polymorphism in healthy and BSE-affected Slovak cattle.Journal of applied genetics · 2009Article
- Regulation of prion protein expression: a potential site for therapeutic intervention in the transmissible spongiform encephalopathies.International journal of biomedical science : IJBS · 2006Article
- Complement lysis activity in autologous plasma is associated with lower viral loads during the acute phase of HIV-1 infection.PLoS medicine · 2006Article
- All-trans retinoic acid down-regulates prion protein expression independently of granulocyte maturation.Leukemia · 2002Article
- Identification of multiple quantitative trait loci linked to prion disease incubation period in mice.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Onset of ataxia and Purkinje cell loss in PrP null mice inversely correlated with Dpl level in brain.The EMBO journal · 2001Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Missense mutations in the prion protein (PrP) gene, overexpression of the cellular isoform of PrP (PrPC), and infection with prions containing the scrapie isoform of PrP (PrPSc) all cause neurodegenerative disease. To understand better the physiology and expression of PrPC, we retrieved mouse PrP gene (Prn-p) yeast artificial chromosome (YAC), cosmid, phage, and cDNA clones. Physical mapping positions Prn-p approximately 300 kb from ecotropic virus integration site number 4 (Evi-4), compatible with failure to detect recombination between Prn-p and Evi-4 in genetic crosses. The Prn-pa allele encompasses three exons, with exons 1 and 2 encoding the mRNA 5' untranslated region. Exon 2 has no equivalent in the Syrian hamster and human PrP genes. The Prn-pb gene shares this intron/exon structure but harbors an approximately 6-kb deletion within intron 2. While the Prn-pb open reading frame encodes two amino acid substitutions linked to prolonged scrapie incubation periods, a deletion of intron 2 sequences also characterizes inbred strains such as RIII/S and MOLF/Ei with shorter incubation periods, making a relationship between intron 2 size and scrapie pathogenesis unlikely. The promoter regions of a and b Prn-p alleles include consensus Sp1 and AP-1 sites, as well as other conserved motifs which may represent binding sites for as yet unidentified transcription factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.