ReviewBreast cancer research and treatment1994
The type I growth factor receptors in human breast cancer.
Review in Breast cancer research and treatment, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- Mechanisms Underlying the Action and Synergism of Trastuzumab and Pertuzumab in Targeting HER2-Positive Breast Cancer.Cancers · 2018Review
- The effects of trastuzumab on HER2-mediated cell signaling in CHO cells expressing human HER2.BMC cancer · 2018Article
- Targeting tumor cells with antibodies enhances anti-tumor immunity.Biophysics reports · 2018Article
- Transcriptome Analysis of the Thymus in Short-Term Calorie-Restricted Mice Using RNA-seq.International journal of genomics · 2018Article
- ERBB3: A potential serum biomarker for early detection and therapeutic target for devil facial tumour 1 (DFT1).PloS one · 2017Article
- Estrongenic steroid hormones in lung cancer.Seminars in oncology · 2014Review
- Smoking out reproductive hormone actions in lung cancer.Molecular cancer research : MCR · 2014Review
- Adaptive Immune Responses and HER2/neu Positive Breast Cancer.Current pathobiology reports · 2013Article
- Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST.Sarcoma · 2012Article
- The in vitro and in vivo anti-tumor effect of KO-202125, a sauristolactam derivative, as a novel epidermal growth factor receptor inhibitor in human breast cancer.Cancer science · 2011Article
- Negative regulation of EGFR-Vav2 signaling axis by Cbl ubiquitin ligase controls EGF receptor-mediated epithelial cell adherens junction dynamics and cell migration.The Journal of biological chemistry · 2011Article
- Inhibition of ErbB2 by herceptin reduces viability and survival, induces apoptosis and oxidative stress in Calu-3 cell line.Molecular and cellular biochemistry · 2011Article
- Distinct roles for Rho versus Rac/Cdc42 GTPases downstream of Vav2 in regulating mammary epithelial acinar architecture.The Journal of biological chemistry · 2010Article
- Effects of chronic vs. intermittent calorie restriction on mammary tumor incidence and serum adiponectin and leptin levels in MMTV-TGF-α mice at different ages.Oncology letters · 2010Article
- A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma.Nature biotechnology · 2009Article
- Neuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1.Molecular and cellular biology · 2007Article
- HER2 gene status in primary breast cancers and matched distant metastases.Breast cancer research : BCR · 2007Article
- Immunohistochemical evaluation of human epidermal growth factor receptor 2 and estrogen and progesterone receptors in breast carcinoma in Jordan.Breast cancer research : BCR · 2005Article
- Clonal selection for transcriptionally active viral oncogenes during progression to cancer.Journal of virology · 2004Article
- Estrogen receptor pathways in lung cancer.Current oncology reports · 2004Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The type 1 family of growth factor receptors includes the EGFR, c-erbB2, c-erbB3, and c-erbB4. All four members of the family are expressed in breast cancer. The EGFR gene and more frequently the c-erbB2 gene are amplified in a proportion of cases. In addition to increased expression as a result of gene amplification, overexpression of perhaps all of the receptors also appears to occur, probably as a result of increased mRNA transcription. Overexpression may have prognostic value and may predict response to current therapies. Finally these GFR proteins represent targets for new types of chemotherapeutic agents.
Indexed as
Identifiers
7912566What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.