ArticleInfection and immunity1994
Protective role for heat shock protein-reactive alpha beta T cells in murine yersiniosis.
Article in Infection and immunity, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 54 citations in OpenAlex.
- Vaccination against Bacterial Infections: Challenges, Progress, and New Approaches with a Focus on Intracellular Bacteria.Vaccines · 2022Review
- B-cell epitopes in GroEL of Francisella tularensis.PloS one · 2014Article
- Immune defense against pneumonic plague.Immunological reviews · 2008Review
- Vaccination with live Yersinia pestis primes CD4 and CD8 T cells that synergistically protect against lethal pulmonary Y. pestis infection.Infection and immunity · 2007Article
- Cell-mediated protection against pulmonary Yersinia pestis infection.Infection and immunity · 2005Article
- Yersinia pestis V protein epitopes recognized by CD4 T cells.Infection and immunity · 2005Article
- Protection afforded by heat shock protein 60 from Francisella tularensis is due to copurified lipopolysaccharide.Infection and immunity · 2004Article
- Functional transfer of Salmonella pathogenicity island 2 to Salmonella bongori and Escherichia coli.Infection and immunity · 2004Article
- Obligatory symbiotic Wolbachia endobacteria are absent from Loa loa.Filaria journal · 2003Article
- Impaired humoral immune response against mycobacterial 65-kDa heat shock protein (HSP65) in patients with inflammatory bowel disease.Digestive diseases and sciences · 2002Article
- Cellular and molecular regulation of vaccination with heat shock protein 60 from Histoplasma capsulatum.Infection and immunity · 2002Article
- Immune response against a cross-reactive epitope on the heat shock protein 60 homologue of Helicobacter pylori.Infection and immunity · 2000Article
- Heat shock protein 70 (hsp70) as a major target of the antibody response in patients with pulmonary cryptococcosis.Clinical and experimental immunology · 1999Article
- Role of heat shock proteins in protection from and pathogenesis of infectious diseases.Clinical microbiology reviews · 1999Review
- Tetracycline therapy targets intracellular bacteria in the filarial nematode Litomosoides sigmodontis and results in filarial infertility.The Journal of clinical investigation · 1999Article
- In vivo tracking and protective properties of Yersinia-specific intestinal T cells.Clinical and experimental immunology · 1998Article
- Clinical role for a superantigen in Yersinia pseudotuberculosis infection.The Journal of clinical investigation · 1997Article
- Immunity against Yersinia enterocolitica by vaccination with Yersinia HSP60 immunostimulating complexes or Yersinia HSP60 plus interleukin-12.Infection and immunity · 1996Article
- Article
- Immortalized B-lymphocytes from rheumatoid synovial tissue show specificity for bacterial HSP 60.Virchows Archiv : an international journal of pathology · 1996Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the role of heat shock proteins (HSP) of Yersinia enterocolitica for the host immune response against this pathogen, we cloned and expressed a 60-kDa HSP of Y. enterocolitica serotype O8. A fragment of Y. enterocolitica O8 HSP60 encoded by amino acids 90 to 286 was sequenced and showed more than 90% homology with HSP60 of Y. enterocolitica O3 and GroEL of Escherichia coli and 59% homology with HSP65 of Mycobacterium bovis. The arthritogenic T-cell epitope of mycobacterial HSP65 (amino acid residues 180 to 188) was not found on Yersinia HSP60. To determine whether Yersinia HSP60 is an immunodominant antigen, the immune responses of Yersinia-infected C57BL/6 mice were analyzed. Yersinia-infected mice evolved a significant serum antibody and splenic T-cell response against Yersinia HSP60. CD4+ alpha beta T-cell clones which were generated from splenic T cells isolated from either Yersinia-infected or Yersinia HSP60-immunized mice, recognized both heat-killed Yersinia serotypes O3 and O8 as well as recombinant Yersinia HSP60 but not heat-killed Yersinia pseudotuberculosis, Salmonella typhimurium, or recombinant HSP65 of Mycobacterium bovis. The adoptive transfer of HSP60-reactive T-cell clones mediated significant protection against a lethal infection with Y. enterocolitica O8. These results indicate that HSP60 of Y. enterocolitica is an immunodominant antigen which is recognized by both antibodies and CD4+ alpha beta T cells. Moreover, this is the first report providing direct evidence that microbial HSP may elicit a protective immune response which is not associated with autoimmunity.
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