ArticleImmunology1994
Modulation of epidermal Langerhans' cell frequency by tumour necrosis factor-alpha.
Article in Immunology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 126 citations in OpenAlex.
- IL-1beta-induced Langerhans' cell migration and TNF-alpha production in human skin: regulation by lactoferrin.Clinical and experimental immunology · 2003Trial
- TNF-α and IL-1β Do Not Induce Langerhans Cell Migration by Inhibiting TGFβ Activation.JID innovations : skin science from molecules to population health · 2021Article
- Changes of Langerhans cells during skin ageing.Postepy dermatologii i alergologii · 2017Article
- Regulation of Dendritic Cell Function in Inflammation.Journal of immunology research · 2015Review
- Age-related Dysregulation of Inflammation and Innate Immunity: Lessons Learned from Rodent Models.Aging and disease · 2011Article
- Aging of the Innate Immune System: An Update.Current immunology reviews · 2011Article
- Chronic ethanol consumption decreases murine Langerhans cell numbers and delays migration of Langerhans cells as well as dermal dendritic cells.Alcoholism, clinical and experimental research · 2008Article
- Roles for IL-1 and TNFalpha in dynamic behavioral responses of Langerhans cells to topical hapten application.Journal of dermatological science · 2007Article
- Langerhans cells from human oral epithelium are more effective at stimulating allogeneic T cells in vitro than Langerhans cells from skin.Clinical and experimental immunology · 2004Article
- Systemic treatment with anti-CD40 antibody stimulates Langerhans cell migration from the skin.Clinical and experimental immunology · 2002Article
- Influence of ageing on Langerhans cell migration in mice: identification of a putative deficiency of epidermal interleukin-1beta.Immunology · 2002Article
- Interleukin (IL)-18 induces Langerhans cell migration by a tumour necrosis factor-alpha- and IL-1beta-dependent mechanism.Immunology · 2001Article
- Activation of skin dendritic cells by immunostimulatory DNA.Springer seminars in immunopathology · 2000Review
- Colonization of in vitro-formed cervical human papillomavirus- associated (pre)neoplastic lesions with dendritic cells: role of granulocyte/macrophage colony-stimulating factor.The American journal of pathology · 1999Article
- Alpha 6 integrins are required for Langerhans cell migration from the epidermis.The Journal of experimental medicine · 1997Article
- Langerhans cells require signals from both tumour necrosis factor-alpha and interleukin-1 beta for migration.Immunology · 1997Article
- An essential role for CD44 variant isoforms in epidermal Langerhans cell and blood dendritic cell function.The Journal of cell biology · 1997Article
- Pattern of cytokine receptors expressed by human dendritic cells migrated from dermal explants.Immunology · 1997Article
- Langerhans' cells produce type IV collagenase (MMP-9) following epicutaneous stimulation with haptens.Immunology · 1997Article
- Cell and molecular biology of chemical allergy.Clinical reviews in allergy & immunology · 1997Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the induction phase of skin sensitization, dendritic cells (DC), many of which bear high levels of antigen, accumulate in lymph nodes draining the site of exposure. These DC derive from epidermal Langerhans' cells (LC) which are induced to migrate from the skin, via the afferent lymphatics, to lymph nodes. We demonstrated previously that intradermal exposure of mice to homologous, but not human, recombinant tumour necrosis factor-alpha (TNF-alpha) also causes an accumulation of DC in draining nodes, the implication being that the local production of this cytokine by epidermal cells provides one stimulus for LC migration. In the present study we have examined the influence of dermal TNF-alpha on the frequency of LC within the epidermis. Intradermal injection of mice with 25 ng or greater murine recombinant TNF-alpha caused a significant reduction in LC numbers within 30 min of exposure. The same treatment did not influence the frequency of Thy-1+ epidermal DC. The density of LC was unaffected by the same amount of human TNF-alpha of comparable specific activity or by murine granulocyte-macrophage colony-stimulating factor (GM-CSF). These data provide additional evidence that TNF-alpha provides an important signal for the migration of LC from the epidermis.
Indexed as
Identifiers
7911448PMC1422348W2419622634What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.