ArticleMammalian genome : official journal of the International Mammalian Genome Society1994
The Myb and Ahi-1 genes are physically very closely linked on mouse chromosome 10.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Distal regulation of c-myb expression during IL-6-induced differentiation in murine myeloid progenitor M1 cells.Cell death & disease · 2016Article
- AHI-1: a novel signaling protein and potential therapeutic target in human leukemia and brain disorders.Oncotarget · 2011Review
- Transgene insertion in proximity to the c-myb gene disrupts erythroid-megakaryocytic lineage bifurcation.Molecular and cellular biology · 2006Article
- Genome-based identification of cancer genes by proviral tagging in mouse retrovirus-induced T-cell lymphomas.Journal of virology · 2003Article
- Long-range effects of retroviral insertion on c-myb: overexpression may be obscured by silencing during tumor growth in vitro.Journal of virology · 2003Article
- Ahi-1, a novel gene encoding a modular protein with WD40-repeat and SH3 domains, is targeted by the Ahi-1 and Mis-2 provirus integrations.Journal of virology · 2002Article
- Retroviral integration at the Epi1 locus cooperates with Nf1 gene loss in the progression to acute myeloid leukemia.Journal of virology · 2001Article
- The c-myc locus is a common integration site in type B retrovirus-induced T-cell lymphomas.Journal of virology · 2000Article
- Article
- Reassessing the role of C-MYB in tumorigenesis.Oncogene · 1999Review
- Studies on the pathology, especially brain lesions, induced by R7, a spontaneous mutant of Moloney murine sarcoma virus 124.The American journal of pathology · 1998Article
- Evi-5, a common site of retroviral integration in AKXD T-cell lymphomas, maps near Gfi-1 on mouse chromosome 5.Journal of virology · 1995Article
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ahi-1 has previously been identified as a common helper provirus integration site on mouse Chromosome (Chr) 10 in 16% of Abelson pre-B-cell lymphomas and shown to be closely linked to the Myb protooncogene. By using long-range restriction mapping, we have mapped the Myb and Ahi-1 regions within a 120-kbp DNA fragment. The Ahi-1 region is located approximately 35 kbp downstream of the Myb gene. A further confirmation of this finding was obtained by screening a mouse YAC library. The three positive clones obtained contained both the Myb and Ahi-1 gene sequences. To test whether provirus integration in the Ahi-1 region enhances the expression of Myb by a cis-acting mechanism, we have also examined Myb gene expression in A-MuLV-induced pre-B-lymphomas. Our data have revealed that there is no clear evidence for such activation in the tumors we have tested, indicating that provirus insertion in the Ahi-1 region is activating a novel gene, apparently involved in tumor formation.
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