ArticleProceedings of the National Academy of Sciences of the United States of America1994
N- and P-type Ca2+ channels are involved in acetylcholine release at a neuroneuronal synapse: only the N-type channel is the target of neuromodulators.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- Identification of a G Protein-Coupled Receptor for Buccalin-Type Peptides in the MolluskACS omega · 2025Article
- Cholinergic depolarization recruits a persistent CaJournal of neurophysiology · 2023Article
- PKC enhances the capacity for secretion by rapidly recruiting covert voltage-gated Ca2+ channels to the membrane.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Direct enhancement of presynaptic calcium influx in presynaptic facilitation at Aplysia sensorimotor synapses.Molecular and cellular neurosciences · 2009Article
- The neuromuscular junctions of the slow and the fast excitatory axon in the closer of the crab Eriphia spinifrons are endowed with different Ca2+ channel types and allow neuron-specific modulation of transmitter release by two neuropeptides.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Cyclic ADP-ribose and calcium-induced calcium release regulate neurotransmitter release at a cholinergic synapse of Aplysia.The Journal of physiology · 1998Article
- Opposite actions of nitric oxide on cholinergic synapses: which pathways?Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Voltage gated calcium channels in molluscs: classification, Ca2+ dependent inactivation, modulation and functional roles.Invertebrate neuroscience : IN · 1996Review
- Inhibition of ACh release at an Aplysia synapse by neurotoxic phospholipases A2: specific receptors and mechanisms of action.The Journal of physiology · 1995Article
- Calcium channel subtypes for the sympathetic and parasympathetic nerves of guinea-pig atria.British journal of pharmacology · 1995Article
- Modulation of ion currents and regulation of transmitter release in short-term synaptic plasticity: the rise and fall of the action potential.Invertebrate neuroscience : IN · 1995Review
- Activity-dependent changes in voltage-dependent calcium currents and transmitter release.Molecular neurobiologyReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cholinergic transmission in an identified neuro-neuronal synapse of the Aplysia buccal ganglion was depressed by application of a partially purified extract of the funnel-web-spider venom (FTx) or of its synthetic analog (sFTx). This specific blocker of voltage-dependent P-type Ca2+ channels did not interfere with the effect of the N-type Ca2+ channel blocker omega-conotoxin, which could further decrease synaptic transmission after a previous application of FTx. Similar results were obtained when the reversal order of application of these two Ca2+ channel blockers was used. Both P- and N-type Ca2+ currents trigger acetylcholine release in the presynaptic neuron. The neuromodulatory effects of FMRF-amide, histamine, and buccalin on transmitter release disappeared after the blockade of the N-type Ca2+ channels but remained still effective in the presence of FTx. These results indicate that only N-type Ca2+ channels appear to be sensitive to the neuromodulators we have identified.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.