ArticleImmunogenetics1994
No dosage effect of recombinational hotspots in the mouse major histocompatibility complex.
Article in Immunogenetics, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Live hot, die young: transmission distortion in recombination hotspots.PLoS genetics · 2007Article
- Persistence and loss of meiotic recombination hotspots.Genetics · 2005Article
- Mouse strains with an active H2-Ea meiotic recombination hot spot exhibit increased levels of H2-Ea-specific DNA breaks in testicular germ cells.Molecular and cellular biology · 2004Article
- Regulation of the Mts1-Mts2-dependent ade6-M26 meiotic recombination hot spot and developmental decisions by the Spc1 mitogen-activated protein kinase of fission yeast.Molecular and cellular biology · 1998Article
- BAC clones and STS markers near the distal breakpoint of the fourth t-inversion, In(17)4d, in the H2-M region on mouse chromosome 17.Mammalian genome : official journal of the International Mammalian Genome Society · 1998Article
- Meiotic recombination hotspots: shaping the genome and insights into hypervariable minisatellite DNA change.Current topics in developmental biology · 1998Review
- Recombination hotspot activity of hypervariable minisatellite DNA requires minisatellite DNA binding proteins.Somatic cell and molecular genetics · 1998Article
- Characterization of recombination in the HLA class II region.American journal of human genetics · 1997Article
- The extent, mechanism, and consequences of genetic variation, for recombination rate.American journal of human genetics · 1996Article
- Localization of bovine lymphocyte antigen (BoLA) DYA and class I loci to different regions of chromosome 23.Mammalian genome : official journal of the International Mammalian Genome Society · 1996Article
- Meiotic recombination at the Lmp2 hotspot tolerates minor sequence divergence between homologous chromosomes.Immunogenetics · 1996Article
- Molecular mapping of a recombination hotspot located in the second intron of the human TAP2 locus.American journal of human genetics · 1995Article
- Recombination in the class III region of the mouse major histocompatibility complex.Immunogenetics · 1994Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The sites of meiotic recombination in the proximal region of the mouse major histocompatibility complex (MHC) are clustered at hotspots. Some MHC haplotypes derived from Asian wild mice increase the frequency of recombination at such hotspots when heterozygous with standard laboratory haplotypes. The wm7 and cas3 haplotypes have a hotspot close to the Lmp-2 gene (Lmp-2 hotspot), and the cas4 haplotype has a hotspot about 100 kilobase (kb) proximal, close to the Pb gene (Pb hotspot). To examine the effect of a double dose of hotspots, we estimated the rate of recombination and determined the location of the breakpoints in crosses of wm7/cas3 and wm7/cas4. In 3570 backcross progeny we identified 29 new recombinants in the H-2K to Ab interval, at a frequency of 0.81%. This frequency is 40-fold higher than in crosses between laboratory haplotypes and very similar to those previously obtained in crosses between these wild and standard laboratory haplotypes. Thus, a double dose of hotspots has no additive effect on the frequency of meiotic recombination. The site-specificity of recombination was also conserved. Twenty-three breakpoints were confined within 5.4 kb in the Lmp-2 hotspot, and six breakpoints from the cas4 cross were located in the Pb hotspot, which we have now confined to a 15 kb segment.
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