ArticleJournal of bacteriology1994
Lipid synthesis in mycobacteria: characterization of the biotin carboxyl carrier protein genes from Mycobacterium leprae and M. tuberculosis.
Article in Journal of bacteriology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 31 citations in OpenAlex.
- GSMN-ML- a genome scale metabolic network reconstruction of the obligate human pathogen Mycobacterium leprae.PLoS neglected tropical diseases · 2020Article
- Differential Expression of MicroRNAs in Leprosy Skin Lesions.Frontiers in immunology · 2017Article
- A chemical proteomics approach to profiling the ATP-binding proteome of Mycobacterium tuberculosis.Molecular & cellular proteomics : MCP · 2013Article
- Crystallization and preliminary X-ray diffraction analysis of biotin acetyl-CoA carboxylase ligase (BirA) from Mycobacterium tuberculosis.Acta crystallographica. Section F, Structural biology and crystallization communications · 2008Article
- Insights on the evolution of metabolic networks of unicellular translationally biased organisms from transcriptomic data and sequence analysis.Journal of molecular evolution · 2005Article
- Characterization of a bifunctional archaeal acyl coenzyme A carboxylase.Journal of bacteriology · 2003Article
- Molecular characterization of Lactobacillus plantarum genes for beta-ketoacyl-acyl carrier protein synthase III (fabH) and acetyl coenzyme A carboxylase (accBCDA), which are essential for fatty acid biosynthesis.Applied and environmental microbiology · 2001Article
- Biochemical and molecular biological characterization of CAC2, the Arabidopsis thaliana gene coding for the biotin carboxylase subunit of the plastidic acetyl-coenzyme A carboxylase.Plant physiology · 1997Article
- Structure of a gene encoding a cytosolic acetyl-CoA carboxylase of hexaploid wheat.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- The genes encoding the biotin carboxyl carrier protein and biotin carboxylase subunits of Bacillus subtilis acetyl coenzyme A carboxylase, the first enzyme of fatty acid synthesis.Journal of bacteriology · 1995Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The causative agents of leprosy and tuberculosis, Mycobacterium leprae and Mycobacterium tuberculosis, have a lipid-rich cell envelope which contributes to virulence and antibiotic resistance. Acyl coenzyme A carboxylase, which catalyzes the first committed step of lipid biosynthesis, consists in mycobacteria of two subunits, one of which is biotinylated. Genes from M. leprae and M. tuberculosis encoding a biotinylated protein have been cloned and sequenced. Analysis of the derived protein sequences demonstrated the presence of biotin-binding sites and putative ATP-bicarbonate interactions sites, consistent with the proteins having a biotin carboxylase function as well as their being biotin carrier proteins.
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