ArticleThe EMBO journal1994
A B-type cyclin negatively regulates conjugation via interacting with cell cycle 'start' genes in fission yeast.
Article in The EMBO journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43 citing papers in PubMed, 92 citations in OpenAlex.
- The Meiosis-Specific Crs1 Cyclin Is Required for Efficient S-Phase Progression and Stable Nuclear Architecture.International journal of molecular sciences · 2021Article
- CDK Regulation of Meiosis: Lessons fromGenes · 2020Review
- CDK contribution to DSB formation and recombination in fission yeast meiosis.PLoS genetics · 2019Article
- Phosphorylation of the RNA-binding protein Zfs1 modulates sexual differentiation in fission yeast.Journal of cell science · 2017Article
- Article
- The DNA damage and the DNA replication checkpoints converge at the MBF transcription factor.Molecular biology of the cell · 2013Article
- Functional cDNA expression cloning: pushing it to the limit.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2012Review
- A quantitative model for cyclin-dependent kinase control of the cell cycle: revisited.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Review
- Article
- The S. pombe SAGA complex controls the switch from proliferation to sexual differentiation through the opposing roles of its subunits Gcn5 and Spt8.Genes & development · 2008Article
- Cdc2p controls the forkhead transcription factor Fkh2p by phosphorylation during sexual differentiation in fission yeast.The EMBO journal · 2008Article
- Evolutionarily divergent type II protein arginine methyltransferase in Trypanosoma brucei.Eukaryotic cell · 2007Article
- Cdk phosphorylation of the Ste11 transcription factor constrains differentiation-specific transcription to G1.Genes & development · 2007Article
- Molecular mechanisms underlying the mitosis-meiosis decision.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2007Review
- Identification of cell cycle-regulated genes in fission yeast.Molecular biology of the cell · 2005Article
- Article
- G(1)/S CDK is inhibited to restrain mitotic onset when DNA replication is blocked in fission yeast.The EMBO journal · 2002Article
- The G1/S cyclin Cig2p during meiosis in fission yeast.Molecular biology of the cell · 2002Article
- A role for the START gene-specific transcription factor complex in the inactivation of cyclin B and Cut2 destruction.Molecular biology of the cell · 2000Article
- A pcl-like cyclin activates the Res2p-Cdc10p cell cycle "start" transcriptional factor complex in fission yeast.Molecular biology of the cell · 2000Article
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
In the fission yeast Schizosaccharomyces pombe, the cdc10+/SWI family members constitute the cell cycle 'start' genes. res1+ and res2+ are the newly identified members of this family and encode putative association partners of the Cdc10 protein. The Pat1 kinase plays a pivotal role in switching between vegetative growth and sexual development, and its inactivation in haploid cells induces unconditional growth arrest and subsequent meiosis. We have identified as an extragenic suppressor of a temperature sensitive pat1-114 mutant, a new B-type cyclin that negatively regulates conjugation by interacting with these 'start' genes. This cyclin, named Cyc17, is highly homologous with Cdc13, but has no detectable activity as a mitotic cyclin. Deletion of cyc17+ markedly enhances conjugation, despite the presence of nitrogen source, and accelerates growth arrest in G1 upon nitrogen starvation. Conversely, overexpression of the cyc17+ gene strongly inhibits conjugation. The cyc17+ gene is transcribed into 3.2 kb poly(A)+ and 3.0 kb poly(A)- RNAs. Only the poly(A)+ species is expressed during vegetative growth and periodically with a peak in the G1 and S phases of the cell cycle. On the other hand, the poly(A)- transcript is highly induced during conjugation. This induction is lost in res2- cells, whereas the poly(A)+ transcript is significantly reduced in res1- cells. However, the mating inhibition as well as the ability to rescue the pat1 mutation by overexpression of res1+ and res2+ are totally abolished in cyc17- cells. Thus, in S.pombe, a B-type cyclin, regulated by the newly identified cell cycle 'start' genes, plays a crucial role in the control of sexual development.
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