ArticleThe Histochemical journal1994
Sympathetic and sensory innervation of the urinary tract in young adult and aged rats: a semi-quantitative histochemical and immunohistochemical study.
Article in The Histochemical journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 61 citations in OpenAlex.
- An adeno-associated viral labeling approach to visualize the meso- and microanatomy of mechanosensory afferents and autonomic innervation of the rat urinary bladder.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Loss of resilience contributes to detrusor underactivity in advanced age.Biogerontology · 2023Article
- Sophisticated regulation of micturition: review of basic neurourology.Journal of exercise rehabilitation · 2021Review
- The aging bladder insights from animal models.Asian journal of urology · 2018Review
- Morphological changes in peri-prostatic sympathetic ganglion cells in aging males.Molecular and clinical oncology · 2017Article
- The link between vascular dysfunction, bladder ischemia, and aging bladder dysfunction.Therapeutic advances in urology · 2017Review
- Neurogenic mechanisms in bladder and bowel ageing.Biogerontology · 2015Review
- Neural control of the lower urinary tract.Comprehensive Physiology · 2015Review
- Characterization of axons expressing the artemin receptor in the female rat urinary bladder: a comparison with other major neuronal populations.The Journal of comparative neurology · 2014Article
- Changes in nerve-mediated contractility of the lower urinary tract in a mouse model of premature ageing.British journal of pharmacology · 2014Article
- Increased alpha1D adrenergic receptor activity and protein expression in the urinary bladder of aged rats.World journal of urology · 2008Article
- The effect of labor and/or ovariectomy on rodent continence mechanism--the neuronal changes.World journal of urology · 2004Article
- Histological and electrical properties of rat dorsal root ganglion neurons innervating the lower urinary tract.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- In vitro functional properties of the rat bladder regenerated by the bladder acellular matrix graft.The Journal of urology · 1998Article
- The hypogastric and thirteenth thoracic ganglia of the rat: effects of age on the neurons and their extracellular environment.Journal of anatomy · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The sympathetic innervation of the urinary tract of young adult (4 months) and aged (24+ months) rats has been examined by glyoxylic acid-induced fluorescence for the detection of noradrenaline and by immunofluorescence using antisera against tyrosine hydroxylase (TH) and neuropeptide Y (NPY). Immunostaining for calcitonin gene-related peptide (CGRP), known to be present in pelvic sensory nerves, was also performed. Semi-quantitative estimations of nerve densities were made of noradrenergic and peptidergic fibres innervating the smooth musculature of the ureter, bladder and urethra, and of the urinary tract vasculature. In the aged rats the overall patterns of innervation remained unchanged. However, with the exception of the vesical vasculature, the density of noradrenergic innervation decreased as did the intensity of histofluorescence. A similar pattern of results was observed by TH and NPY immunofluorescence. The results present evidence for a diminution in the sympathetic control of the urinary tract in aged rats. The pattern and density of CGRP-immunoreactive nerves was unchanged in the aged animals suggesting that pelvic visceral sensory innervation is more resistant to the effects of advancing age.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.