ArticleClinical and experimental immunology1994
Increase of both circulating Th1 and Th2 T lymphocyte subsets in IgA nephropathy.
Article in Clinical and experimental immunology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 49 citations in OpenAlex.
- Molecular Differences in Glomerular Compartment to Distinguish Immunoglobulin A Nephropathy and Lupus Nephritis.Journal of inflammation research · 2024Article
- T lymphocytes in IgA nephropathy.Experimental and therapeutic medicine · 2020Article
- B cell-derived IL-4 acts on podocytes to induce proteinuria and foot process effacement.JCI insight · 2017Article
- Serum Levels of Soluble ST2 and IL-10 Are Associated with Disease Severity in Patients with IgA Nephropathy.Journal of immunology research · 2016Article
- Disruption of Smad4 expression in T cells leads to IgA nephropathy-like manifestations.PloS one · 2013Article
- Pathogenesis of IgA nephropathy.Nature reviews. Nephrology · 2012Review
- TRAC variants associate with IgA nephropathy.Journal of the American Society of Nephrology : JASN · 2009Article
- T cell cytokine polarity as a determinant of immunoglobulin A (IgA) glycosylation and the severity of experimental IgA nephropathy.Clinical and experimental immunology · 2008Article
- Expression of T cell receptor variable region families by bone marrow gammadelta T cells in patients with IgA nephropathy.Clinical and experimental immunology · 2002Article
- For further investigations in IgA nephropathy the approach from phenotype to genotype is welcome.Clinical and experimental immunology · 2002Article
- Increased IL-10 production by stimulated whole blood cultures in primary IgA nephropathy.Clinical and experimental immunology · 1998Article
- Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases.Clinical microbiology reviews · 1996Review
- Monoclonal IgA gammopathy in a well infant.Archives of disease in childhood · 1996Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
IgA nephropathy (IgAN), characterized by glomerular deposition of IgA and frequently elevated plasma IgA levels, has increased T helper cell activity. In vitro measurement of cytokines in supernatant of cultured peripheral lymphocytes revealed conflicting findings. We examined the profile of cytokine mRNA expressed in purified CD4+ cells in patients with IgAN in order to study their pattern of Th1 (releases IL-2 and interferon-gamma (IFN-gamma)) and Th2 (releases IL-4 and IL-5) T cell response. We assessed the circulating CD4+ T cells in patients and normal controls by the expression of messenger RNA (mRNA) for IL-2, IL-4, IL-5 and IFN-gamma. The cytokine mRNAs were analysed with reverse transcription-polymerase chain reaction and were measured semiquantitatively by using a housekeeping gene, beta-actin. Compared with the control subjects, CD4+ T lymphocytes from patients with IgAN expressed a higher level of IL-2 mRNA (P = 0.007), IFN-gamma mRNA (P = 0.04), IL-4 mRNA (P = 0.048), and IL-5 mRNA (P = 0.016). Within these patients with IgAN, a good correlation was demonstrated between the gene expression of cytokines in Th1 or Th2 cells. The IL-2 mRNA levels in Th1 cells from these patients with IgAN also correlated significantly with the IL-4 or IL-5 mRNA levels in their Th2 cells. Our study revealed IgAN is associated with activation in circulating lymphocytes of the IL-2, IFN-gamma, IL-4 and IL-5 gene cluster, a pattern compatible with activation of both the Th1- and Th2-like T lymphocyte population. The increased transcription of these cytokines genes may be contributory to the immunopathologic findings in IgAN.
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