ArticleProceedings of the National Academy of Sciences of the United States of America1994
A primate T-lymphotropic virus, PTLV-L, different from human T-lymphotropic viruses types I and II, in a wild-caught baboon (Papio hamadryas).
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36 citing papers in PubMed, 101 citations in OpenAlex.
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- HTLV-3/4 and simian foamy retroviruses in humans: discovery, epidemiology, cross-species transmission and molecular virology.Virology · 2013Review
- Animal models on HTLV-1 and related viruses: what did we learn?Frontiers in microbiology · 2012Article
- HTLV-3/STLV-3 and HTLV-4 viruses: discovery, epidemiology, serology and molecular aspects.Viruses · 2011Review
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- Development and validation of a multiplex real-time PCR assay for simultaneous genotyping and human T-lymphotropic virus type 1, 2, and 3 proviral load determination.Journal of clinical microbiology · 2009Article
- Genetic characterization of the complete genome of a highly divergent simian T-lymphotropic virus (STLV) type 3 from a wild Cercopithecus mona monkey.Retrovirology · 2009Article
- The receptor complex associated with human T-cell lymphotropic virus type 3 (HTLV-3) Env-mediated binding and entry is distinct from, but overlaps with, the receptor complexes of HTLV-1 and HTLV-2.Journal of virology · 2009Article
- Simian T-lymphotropic virus diversity among nonhuman primates, Cameroon.Emerging infectious diseases · 2009Article
- Construction and characterization of a human T-cell lymphotropic virus type 3 infectious molecular clone.Journal of virology · 2008Article
- Construction and characterization of a full-length infectious simian T-cell lymphotropic virus type 3 molecular clone.Journal of virology · 2007Article
- No genetic evidence for involvement of Deltaretroviruses in adult patients with precursor and mature T-cell neoplasms.Retrovirology · 2007Article
- Human T-cell lymphotropic virus type 3: complete nucleotide sequence and characterization of the human tax3 protein.Journal of virology · 2006Article
- Ancient origin and molecular features of the novel human T-lymphotropic virus type 3 revealed by complete genome analysis.Journal of virology · 2006Article
- Article
- Emergence of unique primate T-lymphotropic viruses among central African bushmeat hunters.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Discovery of a new human T-cell lymphotropic virus (HTLV-3) in Central Africa.Retrovirology · 2005Article
- Molecular epidemiology of simian T-cell lymphotropic virus type 1 in wild and captive sooty mangabeys.Journal of virology · 2005Article
- Divergent simian T-cell lymphotropic virus type 3 (STLV-3) in wild-caught Papio hamadryas papio from Senegal: widespread distribution of STLV-3 in Africa.Journal of virology · 2003Article
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5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Searching for clues to the evolution of the primate T-lymphotropic viruses (PTLVs), which include the human and the simian T-lymphotropic viruses (HTLV and STLV), we have identified another PTLV, which differs sufficiently from the known PTLV-I and PTLV-II types to be designated here PTLV-L. The virus was isolated from a wild-born baboon (Papio hamadryas) from Eritrea. In a cDNA library a 1802-bp-long fragment was identified that extends from the env region, including the complete transmembrane protein gene, to part of the tax/rex gene. Homologies at the nucleotide sequence level of PTLV-L, prototype simian T-lymphotropic virus-PH969, with HTLV-I and -II, respectively, were 62% and 64% overall, 65% and 70% in the env region, and 80% and 80% in the partial tax/rex sequence. In the 5' part of the pX region a significant homology was seen only with HTLV-II (52%). Phylogenetic analysis based on the gene encoding the transmembrane protein indicates that PTLV-L represents a PTLV type with a long independent evolution, longer than any strain within the PTLV-I or PTLV-II groups. The finding of another PTLV type in African baboons is further evidence of the wide variety of PTLV found on this continent. Whether PTLV-L resembles PTLV-I and PTLV-II in the extension of its host range to other primates, including humans, remains to be seen.
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